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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Desvenlafaxine
Molecular formula	C16H25NO2
IUPAC name	4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
Molecular weight	263.381
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.6
Synonyms	O-DESMETHYLVENLAFAXINE (ODV) PDSP2_001787 1-[2-dimethylamino-1-(4-hydroxyphenyl)ethyl]cyclohexanol SMR004701214 413D628 ACMC-20ek0k CAS_386750-22-7 D0O3FG DS-1282 I06-2078 MLS006010042 O-Desmethylvenlafaxine solution, 100 mug/mL in methanol, ampule of 1 mL, certified reference material S-2830 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol TR-029259 93413-62-8 AT-19352 CHEMBL1118 Desvenlafaxine (INN) FT-0654519 Khedezla NSC_6918664 ODV 1-[1-(4-hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol SC-82264 4-[2-Dimethyamino-1-(1-hydroxycyclohexyl)ethyl]phenol Wy-45233 AB01563022_01 BDBM86748 d,l-O-Desmethylvenlafaxine Desvenlafaxine, 97% HSDB 7993 KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethyl-venlafaxine O-Desmethylvenlafaxine 0.1 mg/ml in Methanol Phenol, 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)- 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol ST2410953 4CH-007182 AK-72949 CHEBI:83527 DB06700 DVS 233 J10126 MolPort-003-846-411 O-Desmethylvenlafaxine, analytical standard (RS)-1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol s4113 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol # WY 45,233 A844583 AX8123273 CS-2818 Desvenlafaxine [INN:BAN] GTPL7158 Khedezla (TN) O-desmethyl venlafaxine O-Desmethylvenlafaxine PDSP1_001804 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol SCHEMBL34864 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol X4688 AC1L2NUV BR-72949 D07793 dl-o-desmethylvenlafaxin HY-B0602 LS-178212 O-Desmethylvenlafaxine solution, 1.0 mg/mL in methanol, certified reference material Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]- 4-[1-(1-hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol SW219514-2 AKOS015896311 EC 700-516-2 KB-33580 NCGC00345883-04 O-Desvenlafaxine (S)-Desmethyl Venlafaxine D6 SB17444 4-[2-(dimethylamino)-1-(1-oxidanylcyclohexyl)ethyl]phenol WY-45,233 AB0031560 BCP28517 CTK8E8385 desvenlafaxine(o-desnethylvenfaxine) HMS3652K16 KS-00000FZO o-desmethyl venlafaxine-d10 [ Show all ]
Inchi Key	KYYIDSXMWOZKMP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
PubChem CID	125017
ChEMBL	CHEMBL1118
IUPHAR	N/A
BindingDB	86748
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
556203	Adenosine receptor A1	P30542	ADORA1	Homo sapiens (Human)	326
181575	Adenosine receptor A2b	Q1LZD0	ADORA2B	Bos taurus (Bovine)	332
181578	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
556206	Cannabinoid receptor 1	P21554	CNR1	Homo sapiens (Human)	472
181580	Cannabinoid receptor 2	P34972	CNR2	Homo sapiens (Human)	360
181581	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
556204	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
556205	D(3) dopamine receptor	P19020	Drd3	Rattus norvegicus (Rat)	446
181582	Histamine H2 receptor	P47747	HRH2	Cavia porcellus (Guinea pig)	359
181577	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
181576	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
181583	Muscarinic acetylcholine receptor M3	P20309	CHRM3	Homo sapiens (Human)	590
181579	Muscarinic acetylcholine receptor M4	P08173	CHRM4	Homo sapiens (Human)	479
460838	Muscarinic acetylcholine receptor M5	P08912	CHRM5	Homo sapiens (Human)	532

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