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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Dihydrorotenone
Molecular formula	C23H24O6
IUPAC name	(1S,6R,13S)-16,17-dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one
Molecular weight	396.439
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.2
Synonyms	SR-01000642530-1 [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethyl)-, [2R-(2.alpha.,6a.alpha.,12a.alpha.)]- (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6a-alphah)-one, 1,2,12,12a-alpha-tetrahydro-2-alpha-isopropyl-8,9-dimethoxy- 2-isopropyl-8,9-dimethoxy-1,2,6,6a,12,12a-hexahydrochromeno[3,4-b]furo[2,3-h]chromen-6-one BDBM97131 DTXSID5041227 NSC351138 SR-01000767777-2 (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethyl)-, (2R-(2alpha,6aalpha,12aalpha))- (9CI) 6659-45-6 MolPort-002-893-977 Rotenone, dihydro- (VAN) ZINC2008906 12379-65-6 AC1Q6KP4 NSC-351138 SMR000457416 SR-01000642530-2 (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aalphaH)-one, 1,2,12,12aalpha-tetrahydro-2alpha-isopropyl-8,9-dimethoxy- (8CI) 538CX0LPPO Caswell No. 353 EPA Pesticide Chemical Code 071002 NSC53866 UNII-538CX0LPPO (2r,6as,12as)-8,9-dimethoxy-2-(propan-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6ah)-one CHEMBL267630 NSC 351138 S,S-Dihydrorotenone SR-01000642530 [1]Benzopyrano[3,3-h][1]benzopyran-6(6a.alpha.H)-one, 1,2,12,12a.alpha.-tetrahydro-2.alpha.-isopropyl-8,9-dimethoxy- 2-ISOPROPYL-8,9-DI-MEO-1,2,12,12A-4H-6AH-CHROMENO(3,4-B)FURO(2,3-H)CHROMEN-6-ONE AKOS024419416 Dihydrorotenone (VAN) NSC-53866 SR-01000767777 (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethyl)-, (2R,6aS,12aS)- 6',7'-Dihydrorotenone CCG-53362 MLS000851173 Rotenone, dihydro- WLN: T G5 D6 B666 CV HO MO PO DU- L GU- KTTTT&J IY1&U1 SO1 TO1 1',2'-Dihydrorotenone AC1L6C74 cid_243725 NSC 53866 SCHEMBL19035536 [ Show all ]
Inchi Key	DTFARBHXORYQBF-HBGVWJBISA-N
Inchi ID	InChI=1S/C23H24O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,11,16,20-21H,8,10H2,1-4H3/t16-,20-,21+/m1/s1
PubChem CID	243725
ChEMBL	CHEMBL267630
IUPHAR	N/A
BindingDB	97131
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
68273	Galanin receptor type 3	O60755	GALR3	Homo sapiens (Human)	368
68272	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463

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