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Check the GPCR table for details.
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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
557433	CHEMBL3976282	C24H30N4OS2	454.651	6 / 1	5.5	No
553272	3,3-difluoro-4-(4-methoxyphenyl)-1-phenylazetidin-2-one	C16H13F2NO2	289.282	4 / 0	3.2	Yes
557532	(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H18N4O2	322.368	4 / 1	3.2	Yes
464333	CHEMBL3633714	C19H22N2O3	326.396	3 / 2	2.8	Yes
464334	CHEMBL3633715	C19H22N2O3	326.396	3 / 2	2.8	Yes
464439	CHEMBL3633895	C18H20N2O3	312.369	3 / 2	2.4	Yes
464440	CHEMBL3633881	C18H20N2O3	312.369	3 / 2	2.4	Yes
464728	CHEMBL3633891	C17H19ClN2O	302.802	2 / 2	3.3	Yes
557935	(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide	C18H14F4N4O3	410.329	9 / 1	4.1	Yes
557967	(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
557972	(S)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(p-tolyl)ethyl)acetamide	C19H19FN4O2	354.385	5 / 1	3.6	Yes
558003	(S)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C20H22N4O3	366.421	5 / 1	3.5	Yes
558236	(S)-N-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)acetamide	C17H15ClN4O2	342.783	4 / 1	3.4	Yes
558318	(S)-N-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C19H16F4N4O3	424.356	9 / 1	3.8	Yes
558445	SCHEMBL17767211	C19H18F2N4O4	404.374	8 / 1	3.7	Yes
553464	L-phenylalanine	C9H11NO2	165.192	3 / 2	-1.5	Yes
558741	N-(3-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C17H15ClN4O2	342.783	4 / 1	3.5	Yes
558876	SCHEMBL17767031	C19H20N4O3	352.394	5 / 1	3.1	Yes
558994	SCHEMBL17767119	C18H16F2N4O2	358.349	6 / 1	3.4	Yes
559487	SCHEMBL17767056	C18H17FN4O2	340.358	5 / 1	3.3	Yes
559740	SCHEMBL17767021	C19H20N4O3	352.394	5 / 1	3.1	Yes
559857	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
559993	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]triazin-3 (4H)-yl)acetamide	C19H17F3N4O3	406.365	8 / 1	3.7	Yes
560004	SCHEMBL17766994	C19H19FN4O2	354.385	5 / 1	3.6	Yes
560073	(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamide	C18H15F3N4O2	376.339	7 / 1	3.7	Yes
560110	SCHEMBL17767089	C19H16F4N4O4	440.355	10 / 1	4.1	Yes
560139	N-(4-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C17H15ClN4O2	342.783	4 / 1	3.5	Yes
560422	(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamide	C19H17F3N4O3	406.365	8 / 1	3.7	Yes
560426	(S)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H17F3N4O2	390.366	7 / 1	4.1	Yes
560472	(S)-2-(5-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H17FN4O2	340.358	5 / 1	3.3	Yes
560533	SCHEMBL17767032	C18H14F4N4O3	410.329	9 / 1	4.1	Yes
477507	CHEMBL3633888	C17H16ClFN2O2	334.775	3 / 2	3.2	Yes
478869	CHEMBL3633716	C19H22N2O4	342.395	4 / 3	1.8	Yes
553947	D04ZMM	C20H19N3O4	365.389	4 / 3	3.3	Yes
479395	CHEMBL3633892	C17H19ClN2O	302.802	2 / 2	3.2	Yes
561545	(S)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C18H17ClN4O3	372.809	5 / 1	3.4	Yes
561782	SCHEMBL17767152	C19H17F3N4O2	390.366	7 / 1	4.2	Yes
562253	(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H17FN4O2	340.358	5 / 1	3.3	Yes
562487	(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
483399	CHEMBL3633890	C19H22N2O4	342.395	4 / 2	2.4	Yes
562562	(S)-N-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C18H14F4N4O2	394.33	8 / 1	3.8	Yes
562727	(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C19H20N4O4	368.393	6 / 1	2.8	Yes
484606	TC-O 9311	C20H19N3O4	365.389	4 / 3	3.3	Yes
563043	(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C19H20N4O4	368.393	6 / 1	2.8	Yes
563198	(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide	C19H17F3N4O4	422.364	9 / 1	4.0	Yes
563393	(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)propyl)acetamide	C19H17F3N4O3	406.365	8 / 1	4.5	Yes
563462	(S)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide	C19H17F3N4O4	422.364	9 / 1	4.0	Yes
563563	(S)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide	C19H17F3N4O4	422.364	9 / 1	4.0	Yes
563571	SCHEMBL17767147	C19H20N4O2	336.395	4 / 1	3.5	Yes
563883	(S)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O2	336.395	4 / 1	3.5	Yes
563964	(S)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
564019	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C18H18N4O3	338.367	5 / 1	2.8	Yes
489664	CHEMBL3633896	C17H17ClN2O2	316.785	2 / 2	3.1	Yes
215744	JNJ-63533054	C17H17ClN2O2	316.785	2 / 2	3.1	Yes
564228	N-(2-chloro-4-methoxyphenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C18H17ClN4O3	372.809	5 / 1	3.5	Yes
564264	(S)-2-(8-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H17FN4O2	340.358	5 / 1	3.3	Yes
564315	(R)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(2-phenylpropyl)acetamide	C18H18N4O2	322.368	4 / 1	3.2	Yes
490819	CHEMBL3633885	C17H16Cl2N2O2	351.227	2 / 2	3.7	Yes
491337	AC1LTB7C	C17H18N2O2	282.343	2 / 2	2.4	Yes
564596	SCHEMBL17767153	C18H15F3N4O3	392.338	8 / 1	3.8	Yes
492006	CHEMBL3633884	C17H16Cl2N2O2	351.227	2 / 2	3.7	Yes
492141	CHEMBL3633894	C17H17NO2S	299.388	3 / 1	3.6	Yes
492624	CHEMBL3633883	C18H17F3N2O3	366.34	6 / 2	3.6	Yes
564870	(S)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C18H16Cl2N4O3	407.251	5 / 1	4.0	Yes
564998	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
494376	CHEMBL3633879	C18H17N3O2	307.353	3 / 2	2.2	Yes
565332	(S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-phenylethyl)acetamide	C17H16N4O2	308.341	4 / 1	2.8	Yes
565516	SCHEMBL17767093	C18H17FN4O3	356.357	6 / 1	2.9	Yes
565529	(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C18H17FN4O3	356.357	6 / 1	2.9	Yes
565830	(S)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H16Cl2N4O2	391.252	4 / 1	4.4	Yes
565847	(S)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C19H20N4O4	368.393	6 / 1	2.8	Yes
565922	(S)-2-(5-methyl-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O2	336.395	4 / 1	3.5	Yes
554662	L-tryptophan	C11H12N2O2	204.229	3 / 3	-1.1	Yes
565945	(S)-2-(8-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C18H17FN4O3	356.357	6 / 1	2.9	Yes
566161	(S)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H17ClN4O2	356.81	4 / 1	3.8	Yes
566310	(S)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
566405	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(5-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
566466	(S)-2-(7-chloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C18H17ClN4O2	356.81	4 / 1	3.8	Yes
566530	N-(4-methylphenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C18H18N4O2	322.368	4 / 1	3.2	Yes
500597	AC1M48VO	C17H17ClN2O2	316.785	2 / 2	3.1	Yes
566894	SCHEMBL17766920	C18H13F5N4O3	428.319	10 / 1	4.2	Yes
501001	CHEMBL3633717	C25H26N2O3	402.494	3 / 2	4.4	Yes
566947	(S)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide	C19H17F3N4O4	422.364	9 / 1	4.0	Yes
567068	(S)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamide	C18H14F4N4O2	394.33	8 / 1	3.8	Yes
567189	SCHEMBL17767170	C19H20N4O4	368.393	6 / 1	2.8	Yes
567309	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(8-methyl-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)acetamide	C19H20N4O3	352.394	5 / 1	3.1	Yes
554876	4-cyclohexyl-N-(2-methylphenyl)benzenesulfonamide	C19H23NO2S	329.458	3 / 1	5.2	No
502845	CHEMBL3633878	C18H20N2O2	296.37	2 / 2	2.8	Yes
567606	(S)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)-N-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamide	C19H17F3N4O3	406.365	8 / 1	3.7	Yes
504419	CHEMBL3633880	C17H17FN2O2	300.333	3 / 2	2.5	Yes
567969	(S)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O2	336.395	4 / 1	3.5	Yes
505224	CHEMBL3633886	C17H16Cl2N2O2	351.227	2 / 2	3.7	Yes
568103	(S)-2-(8-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C19H20N4O2	336.395	4 / 1	3.5	Yes
568343	(S)-N-(1-(4-methoxyphenyl)propan-2-yl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide	C19H20N4O3	352.394	5 / 1	3.3	Yes
508068	CHEMBL3633889	C17H16BrClN2O2	395.681	2 / 2	3.8	Yes
568855	SCHEMBL17766940	C18H16F2N4O3	374.348	7 / 1	3.7	Yes
510069	CHEMBL3633721	C17H17ClN2O2	316.785	2 / 2	3.1	Yes
510344	CHEMBL3633887	C17H16Cl2N2O2	351.227	2 / 2	3.7	Yes
569734	(S)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-methoxyphenyl)ethyl)acetamide	C18H17ClN4O3	372.809	5 / 1	3.4	Yes
569846	(S)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-p-tolylethyl)acetamide	C20H22N4O2	350.422	4 / 1	3.9	Yes

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