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GPCR

NameProbable G-protein coupled receptor 139
SpeciesHomo sapiens (Human)
GeneGPR139
SynonymG(q)-coupled orphan receptor GPRg1
G-protein-coupled receptor PGR3
GPR139
GPRG1
DiseaseN/A
Length353
Amino acid sequenceMEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProtQ6DWJ6
Protein Data BankN/A
GPCR-HGmod modelQ6DWJ6
3D structure modelThis predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3632455
IUPHAR130
DrugBankN/A

Ligand

Name(R)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(2-phenylpropyl)acetamide
Molecular formulaC18H18N4O2
IUPAC name2-(4-oxo-1,2,3-benzotriazin-3-yl)-N-[(2R)-2-phenylpropyl]acetamide
Molecular weight322.368
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.2
SynonymsUS9556130, test 80
NHHIFMSLOXYVBO-ZDUSSCGKSA-N
AC1OYEGA
SCHEMBL17767133
2-(4-oxo-1,2,3-benzotriazin-3-yl)-N-[(2R)-2-phenylpropyl]acetamide
[ Show all ]
Inchi KeyNHHIFMSLOXYVBO-ZDUSSCGKSA-N
Inchi IDInChI=1S/C18H18N4O2/c1-13(14-7-3-2-4-8-14)11-19-17(23)12-22-18(24)15-9-5-6-10-16(15)20-21-22/h2-10,13H,11-12H2,1H3,(H,19,23)/t13-/m0/s1
PubChem CID8036887
ChEMBLN/A
IUPHARN/A
BindingDB263508
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4448.0 nMN/ABindingDB

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