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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	N-(2-chloro-4-methoxyphenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide
Molecular formula	C18H17ClN4O3
IUPAC name	N-[2-(2-chloro-4-methoxyphenyl)ethyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide
Molecular weight	372.809
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.5
Synonyms	NCYGXXHWJXKIOW-UHFFFAOYSA-N BDBM263509 SCHEMBL17767151 US9556130, test 81
Inchi Key	NCYGXXHWJXKIOW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H17ClN4O3/c1-26-13-7-6-12(15(19)10-13)8-9-20-17(24)11-23-18(25)14-4-2-3-5-16(14)21-22-23/h2-7,10H,8-9,11H2,1H3,(H,20,24)
PubChem CID	121349737
ChEMBL	N/A
IUPHAR	N/A
BindingDB	263509
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	117.0 nM	N/A	BindingDB

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