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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	(S)-N-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3 (4H)-yl)acetamide
Molecular formula	C17H15ClN4O2
IUPAC name	N-[(1S)-1-(4-chlorophenyl)ethyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide
Molecular weight	342.783
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.4
Synonyms	ZINC6671934 BDBM263391 SCHEMBL17766973 BRVHTHJIFYTNJL-NSHDSACASA-N US9556130, test 8 AC1OYEL6 N-[(1S)-1-(4-chlorophenyl)ethyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide [ Show all ]
Inchi Key	BRVHTHJIFYTNJL-NSHDSACASA-N
Inchi ID	InChI=1S/C17H15ClN4O2/c1-11(12-6-8-13(18)9-7-12)19-16(23)10-22-17(24)14-4-2-3-5-15(14)20-21-22/h2-9,11H,10H2,1H3,(H,19,23)/t11-/m0/s1
PubChem CID	8036946
ChEMBL	N/A
IUPHAR	N/A
BindingDB	263391
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	228.0 nM	N/A	BindingDB

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