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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	L-phenylalanine
Molecular formula	C9H11NO2
IUPAC name	(2S)-2-amino-3-phenylpropanoic acid
Molecular weight	165.192
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-1.5
Synonyms	DB-029978 .beta.-Phenyl-L-alanine Fenilalanina [Spanish] 1usi K018 34149-EP2305825A1 L-2-Amino-3-phenylpropionic acid 801204-11-5 AK-46761 L-Phenylalanine, 99%, FCC alpha-Aminohydrocinnamic acid L-Phenylalanine, reagent grade, >=98% BDBM18073 (-)-beta-Phenylalanine bmse000921 (S)-2-Amino-3-phenylpropanoic acid CHEBI:17295 (S)-alpha-Aminobenzenepropanoic acid phenylalanine Phenylalaninum RP22793 Z1258578341 LS-1515 NCGC00013103-03 NCIStruc1_000204 (S)-Phenylalanine EINECS 200-568-1 125851-EP2284178A2 H-Phe-OH 3-Phenylalanine L-.beta.-Phenylalanine 47E5O17Y3R L-Antibiotic FN 1636 AB02575 L-Phenylalanine (JP17) Alanine, 3-phenyl- L-Phenylalanine, BioUltra, >=99.0% (NT) AN-23734 beta-Phenyl-alpha-alanine (2S)-2-amino-3-phenylpropanoic acid BR-25441 (S)-alpha-Amino-benzenepropanoate CS-2315 NSC-9959 Phenylalanine (VAN) PubChem11004 ST2413190 L-Phenylalanine, Vetec(TM) reagent grade, >=98% MCULE-5960921520 NCGC00095047-01 D0R1CR .beta.-Phenyl-.alpha.-alanine FEMA No. 3585 1f2p Hydrocinnamic acid, .alpha.-amino- 34149-EP2301939A1 L-2-Amino-3-phenylpropanoic acid 63P912 L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME AC1L1LVU L-Phenylalanine, 98.5-101.0%, specified according to the requirements of USP alpha-Amino-beta-phenylpropionic acid, L- L-Phenylalanine, Pharmaceutical Secondary Standard; Certified Reference Material ANW-34771 bmse000045 (S)-.alpha.-Aminobenzenepropanoic acid CCG-37572 (S)-alpha-Amino-beta-phenylpropionic acid Phenyl-.alpha.-alanine Phenylalanine, European Pharmacopoeia (EP) Reference Standard RP22791 UNII-8P946UF12S component COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylaniline NCGC00013103 NCGC00095047-04 DB00120 .beta.-Phenylalanine GTPL3313 2-Amino-3-phenylpropionic acid, L- KB-53349 34149-EP2311850A1 L-Alanine, 3-phenyl- A5737 L-Phenylalanine (H-Phe-OH) AKOS010373257 L-Phenylalanine, 99%, natural, FCC, FG alpha-Aminohydrocinnamic acid, L- L-Phenylalanine, SAJ special grade, >=99.0% Benzenepropanoic acid, .alpha.-amino-, (S)- (-)-phenylalanine bmse001016 (S)-2-Amino-3-phenylpropionate CHEMBL301523 (S)-alpha-Aminohydrocinnamate NCIStruc2_000248 Phenylalanine (L-Phenylalanine) Phenylalaninum [Latin] SC-09766 ZINC105196 M-5935 NCGC00013103-04 .alpha.-Amino-.beta.-phenylpropionic acid endophenyl 125851-EP2284179A2 HSDB 1825 L-2-Amino-3-phenyl propionic acid 5297-02-9 L-Phe AB1003608 L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI) Alanine, phenyl- L-Phenylalanine, certified reference material, TraceCERT(R) AN-38311 beta-Phenyl-L-alanine (L)-Phenylalanine BR-46761 (S)-alpha-Amino-benzenepropanoic acid CTK2F1892 P0134 Phenylalanine [USAN:INN:JAN] Q-201326 TR-030654 L-Phenylalanine, Vetec(TM), 98.5% MFCD00064227 NCGC00095047-02 DB-016441 .beta.-Phenyl-.alpha.-alanine, l- fenilalanina 1F9436B3-8B0D-4AC6-A004-4249B0BDA436 Hydrocinnamic acid, alpha-amino- 34149-EP2305688A1 L-2-Amino-3-phenylpropionate 67675-33-6 L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; 303-47-9 OCHRATOXINA; 673-06-3 D-PHENYL) AJ-11166 L-Phenylalanine, 99% alpha-Aminohydrocinnamate L-Phenylalanine, PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture AS-14129 (-)-.beta.-Phenylalanine bmse000900 (S)-2-amino-3-phenylpropanoate CCRIS 4254 (S)-alpha-Aminobenzenepropanoate Phenylalamine Phenylalanine, L- RP22792 UNII-N7U7BXP2OI component COLNVLDHVKWLRT-QMMMGPOBSA-N L-[2,3,4,5,6-3H]phenylalanine NCGC00013103-02 NCI9959 DTXSID4040763 10549-09-4 H-Phe-2-Chlorotrityl Resin 3-Phenyl-L-alanine L-(-)-PHENYLALANINE 3617-44-5 L-Alanine, phenyl- AB0013977 L-Phenylalanine (JP15) AKOS015853585 L-Phenylalanine, analytical standard, for Nitrogen Determination According to Kjeldahl Method AM20060774 Benzenepropanoic acid, alpha-amino-, (S)- (2S)-2-amino-3-phenyl-propanoic acid BP-20538 (S)-2-Amino-3-phenylpropionic acid COLNVLDHVKWLRT-QMMMGPOBSA-N (S)-alpha-Aminohydrocinnamic acid NSC 79477 Phenylalanine (USP/INN) PheOH SCHEMBL8119 L-Phenylalanine, United States Pharmacopeia (USP) Reference Standard M02961 NCGC00013103-05 .alpha.-Aminohydrocinnamic acid F0001-2360 125851-EP2295422A2 HY-N0215 34149-EP2289892A1 L-2-amino-3-phenyl-propionic acid 63-91-2 L-phenyl Alanine AC-22417 L-Phenylalanine, 98.5+% Alanine, phenyl-, L- L-Phenylalanine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0% Antibiotic FN 1636 beta-Phenylalnine, (-)- (S)-(-)-Phenylalanine C00079 (S)-alpha-Amino-beta-phenylpropionate D00021 phe Phenylalanine [USAN:USP:INN:JAN] racemic phenylalanine UNII-47E5O17Y3R L-PHENYLALININE MolPort-001-757-101 NCGC00095047-03 [ Show all ]
Inchi Key	COLNVLDHVKWLRT-QMMMGPOBSA-N
Inchi ID	InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
PubChem CID	6140
ChEMBL	N/A
IUPHAR	3313
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	320000.0 nM	PMID24826842	IUPHAR
IC50	31000.0 nM	PMID26349500	IUPHAR
Ki	872000.0 nM	PMID26349500	IUPHAR

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