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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	(S)-N-(1-(4-methoxyphenyl)ethyl)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetamide
Molecular formula	C19H20N4O3
IUPAC name	N-[(1S)-1-(4-methoxyphenyl)ethyl]-2-(6-methyl-4-oxo-1,2,3-benzotriazin-3-yl)acetamide
Molecular weight	352.394
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	OOURTFAADXDITC-ZDUSSCGKSA-N SCHEMBL17767154 BDBM263464 US9556130, test 29
Inchi Key	OOURTFAADXDITC-ZDUSSCGKSA-N
Inchi ID	InChI=1S/C19H20N4O3/c1-12-4-9-17-16(10-12)19(25)23(22-21-17)11-18(24)20-13(2)14-5-7-15(26-3)8-6-14/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
PubChem CID	121349740
ChEMBL	N/A
IUPHAR	N/A
BindingDB	263464
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	915.0 nM	N/A	BindingDB

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