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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	SCHEMBL17767093
Molecular formula	C18H17FN4O3
IUPAC name	2-(5-fluoro-4-oxo-1,2,3-benzotriazin-3-yl)-N-[(1S)-1-(4-methoxyphenyl)ethyl]acetamide
Molecular weight	356.357
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.9
Synonyms	(s)-2-(5-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-(4-methoxyphenyl)ethyl)acetamide US9556130, test 33 BDBM263468
Inchi Key	POOIUAVPFUNLNL-NSHDSACASA-N
Inchi ID	InChI=1S/C18H17FN4O3/c1-11(12-6-8-13(26-2)9-7-12)20-16(24)10-23-18(25)17-14(19)4-3-5-15(17)21-22-23/h3-9,11H,10H2,1-2H3,(H,20,24)/t11-/m0/s1
PubChem CID	121349688
ChEMBL	N/A
IUPHAR	N/A
BindingDB	263468
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4850.0 nM	N/A	BindingDB

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