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GPCR

NameProbable G-protein coupled receptor 139
SpeciesHomo sapiens (Human)
GeneGPR139
SynonymG(q)-coupled orphan receptor GPRg1
G-protein-coupled receptor PGR3
GPR139
GPRG1
DiseaseN/A
Length353
Amino acid sequenceMEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProtQ6DWJ6
Protein Data BankN/A
GPCR-HGmod modelQ6DWJ6
3D structure modelThis predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3632455
IUPHAR130
DrugBankN/A

Ligand

NameCHEMBL3633878
Molecular formulaC18H20N2O2
IUPAC name3-methyl-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Molecular weight296.37
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP2.8
SynonymsAC1ONG7I
3-methyl-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
BDBM50132137
ZINC5171629
Inchi KeySULDFGHKRPBUKM-AWEZNQCLSA-N
Inchi IDInChI=1S/C18H20N2O2/c1-13-7-6-10-16(11-13)18(22)19-12-17(21)20-14(2)15-8-4-3-5-9-15/h3-11,14H,12H2,1-2H3,(H,19,22)(H,20,21)/t14-/m0/s1
PubChem CID7534868
ChEMBLCHEMBL3633878
IUPHARN/A
BindingDB50132137
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5024.0 nMPMID26396690BindingDB,ChEMBL
Emax137.0 %PMID26396690ChEMBL

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