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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	TC-O 9311
Molecular formula	C20H19N3O4
IUPAC name	1-[(3,5-dimethoxybenzoyl)amino]-3-naphthalen-1-ylurea
Molecular weight	365.389
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	3.3
Synonyms	1-[(3,5-dimethoxybenzoyl)amino]-3-naphthalen-1-ylurea BCP28396 3,5-Dimethoxybenzoic acid 2-[(1-naphthalenylamino)carbonyl]hydrazide CHEMBL3633893 AC1MOYX6 N'-[[(1-Naphthyl)amino]carbonyl]-3,5-dimethoxybenzhydrazide 2-(3,5-dimethoxybenzoyl)-N-(1-naphthyl)hydrazinecarboxamide BDBM50131899 ZINC2761895 444932-31-4 MCULE-8922053220 AKOS003793615 STK959982 2-[(3,5-dimethoxyphenyl)carbonyl]-N-(naphthalen-1-yl)hydrazinecarboxamide MolPort-001-676-660 [ Show all ]
Inchi Key	KPTMSQHTGZMEFU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25)
PubChem CID	3376937
ChEMBL	CHEMBL3633893
IUPHAR	N/A
BindingDB	50131899
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	43.0 nM	PMID26396690	BindingDB,ChEMBL
Emax	125.0 %	PMID26396690	ChEMBL

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