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| Name | Cholecystokinin receptor type A |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | CCKAR |
| Synonym | cholecystokinin-1 receptor CCK1-R CCK1 receptor CCK-AR CCK-A receptor [ Show all ] |
| Disease | Pancreatic cancer; Obesity Eating disorder Pancreatic disease Gallstone prophylaxis; Obesity Gastrointestinal disease [ Show all ] |
| Length | 428 |
| Amino acid sequence | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ |
| UniProt | P32238 |
| Protein Data Bank | 1d6g |
| GPCR-HGmod model | P32238 |
| 3D structure model | This structure is from PDB ID 1d6g. |
| BioLiP | BL0007611 |
| Therapeutic Target Database | T28330 |
| ChEMBL | CHEMBL1901 |
| IUPHAR | 76 |
| DrugBank | BE0000402 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 73 |  CHEMBL504861 | C34H31FN4O4 | 578.644 | 7 / 1 | 6.3 | No |
| 1040 |  CHEMBL217353 | C19H19BrN4O3S2 | 495.41 | 7 / 0 | 3.5 | Yes |
| 1319 |  CHEMBL389713 | C31H36N6O5 | 572.666 | 7 / 2 | 4.6 | No |
| 1869 |  CHEMBL261682 | C20H19BrN4O3S | 475.361 | 6 / 1 | 3.3 | Yes |
| 3212 |  CHEMBL2017692 | C38H34N6O2 | 606.73 | 4 / 1 | 5.8 | No |
| 4228 |  CHEMBL570521 | C21H15Cl3N4O3S2 | 541.846 | 7 / 2 | 6.0 | No |
| 5651 |  CCK-A Agonist 34 | C35H32FN5O4 | 605.67 | 6 / 1 | 5.7 | No |
| 5835 |  BDBM50321606 | C80H98N18O14 | 1535.78 | 17 / 18 | 2.2 | No |
| 5991 |  CCK-A Agonist 20 | C37H36N4O4 | 600.719 | 4 / 1 | 6.4 | No |
| 6100 |  CHEMBL566177 | C25H18BrCl2FN4O5S | 656.304 | 9 / 2 | 5.5 | No |
| 6449 |  CHEMBL404967 | C30H34N6O6 | 574.638 | 7 / 2 | 4.1 | No |
| 6451 |  CHEMBL565298 | C22H15BrClFN4O5S2 | 613.857 | 10 / 3 | 5.1 | No |
| 7056 |  CHEMBL357983 | C30H34N4O6 | 546.624 | 6 / 3 | 3.8 | No |
| 7354 |  CHEMBL249763 | C26H24N2O3 | 412.489 | 4 / 1 | 5.4 | No |
| 8170 |  CHEMBL248552 | C26H23ClN2O4 | 462.93 | 5 / 1 | 5.6 | No |
| 8524 |  CHEMBL217715 | C19H19ClN4O4S2 | 466.955 | 8 / 1 | 3.8 | Yes |
| 9394 |  CHEMBL1773888 | C33H31N5O2 | 529.644 | 6 / 0 | 5.8 | No |
| 10559 |  CHEMBL3143146 | C45H58N8O7S | 855.068 | 8 / 7 | 5.5 | No |
| 10561 |  CHEMBL341403 | C45H58N8O7S | 855.068 | 8 / 7 | 5.5 | No |
| 521789 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 13883 |  CHEMBL380907 | C32H41N5O3 | 543.712 | 5 / 1 | 5.9 | No |
| 521934 |  AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
| 18620 |  CHEMBL390276 | C32H32N4O5 | 552.631 | 6 / 2 | 5.4 | No |
| 522106 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522184 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22213 |  CHEMBL410905 | C20H20BrN3O3S2 | 494.422 | 6 / 1 | 4.9 | Yes |
| 26112 |  CHEMBL476095 | C28H26Cl2N4O2 | 521.442 | 4 / 0 | 6.3 | No |
| 27222 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27978 |  CHEMBL473457 | C32H28F2N4O2 | 538.599 | 6 / 0 | 6.5 | No |
| 28646 |  CHEMBL507051 | C37H38N6O5 | 646.748 | 7 / 3 | 5.4 | No |
| 29112 |  CHEMBL2017824 | C38H34N6O2 | 606.73 | 4 / 1 | 5.8 | No |
| 32558 |  CHEMBL2372078 | C55H72N12O17S3 | 1269.43 | 21 / 15 | -5.2 | No |
| 32559 |  CHEMBL238269 | C55H72N12O17S3 | 1269.43 | 21 / 15 | -5.2 | No |
| 34077 |  CCK-A Agonist 30 | C35H37N5O4 | 591.712 | 5 / 1 | 5.5 | No |
| 34585 |  CHEMBL449681 | C36H38N6O3 | 602.739 | 6 / 1 | 5.9 | No |
| 34586 |  CHEMBL505432 | C36H38N6O3 | 602.739 | 6 / 1 | 5.9 | No |
| 34620 |  CHEMBL473865 | C31H28FN5O2 | 521.596 | 6 / 0 | 5.4 | No |
| 35579 |  CHEMBL478397 | C34H34N4O2 | 530.672 | 4 / 0 | 7.1 | No |
| 35764 |  CHEMBL269790 | C28H34N4O4 | 490.604 | 5 / 2 | 5.3 | No |
| 35858 |  CHEMBL571832 | C22H19ClN4O3S2 | 486.989 | 7 / 1 | 4.9 | Yes |
| 36828 |  CHEMBL566574 | C24H16BrCl2FN4O5S | 642.277 | 9 / 3 | 5.2 | No |
| 37014 |  GI-181771X | C34H31N5O6 | 605.651 | 6 / 3 | 4.3 | No |
| 37016 |  GW7854 | C34H31N5O6 | 605.651 | 6 / 3 | 4.3 | No |
| 38489 |  CHEMBL384126 | C18H17ClN4O3S2 | 436.929 | 7 / 1 | 3.2 | Yes |
| 38518 |  CHEMBL515161 | C31H29N5O2 | 503.606 | 5 / 0 | 5.6 | No |
| 522678 |  CHEMBL3736433 | C14H21BN2O2 | 260.144 | 4 / 2 | N/A | N/A |
| 40931 |  CHEMBL1269264 | C36H32N6O2 | 580.692 | 4 / 1 | 5.5 | No |
| 41202 |  CHEMBL294329 | C33H40F3N9O7 | 731.734 | 14 / 7 | N/A | No |
| 42334 |  CHEMBL374325 | C59H73N9O15 | 1148.28 | 17 / 11 | 1.2 | No |
| 42865 |  CHEMBL259557 | C32H37N5O4S | 587.739 | 6 / 1 | 5.7 | No |
| 42881 |  CHEMBL412282 | C19H20BrN5O3S | 478.365 | 6 / 1 | 3.7 | Yes |
| 43467 |  CHEMBL515887 | C31H28FN5O2 | 521.596 | 6 / 0 | 5.4 | No |
| 43983 |  CHEMBL227277 | C32H37N5O5 | 571.678 | 6 / 2 | 5.0 | No |
| 44207 |  Cipargamin | C19H14Cl2FN3O | 390.239 | 3 / 3 | 3.9 | Yes |
| 44773 |  CHEMBL1773891 | C33H29N5O3 | 543.627 | 7 / 0 | 5.2 | No |
| 45733 |  CHEMBL478398 | C33H30N4O3 | 530.628 | 5 / 0 | 6.1 | No |
| 45902 |  CHEMBL347329 | C30H30N4O3 | 494.595 | 4 / 2 | 5.1 | No |
| 45905 |  CHEMBL357502 | C30H30N4O3 | 494.595 | 4 / 2 | 5.1 | No |
| 46580 |  CHEMBL437908 | C18H17ClN4O3S2 | 436.929 | 7 / 1 | 3.8 | Yes |
| 48423 |  CHEMBL1210154 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 48471 |  SCHEMBL4318956 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 50137 |  CHEMBL1773887 | C32H29N5O2 | 515.617 | 6 / 0 | 5.5 | No |
| 52903 |  CHEMBL453083 | C32H31N5O2 | 517.633 | 5 / 0 | 5.7 | No |
| 52951 |  CHEMBL59865 | C33H43N7O7 | 649.749 | 8 / 7 | -1.0 | No |
| 53309 |  CHEMBL216559 | C18H19N5O3S2 | 417.502 | 8 / 2 | 2.5 | Yes |
| 55046 |  CHEMBL504707 | C35H35N5O4 | 589.696 | 7 / 0 | 5.6 | No |
| 55047 |  CHEMBL502924 | C35H35N5O4 | 589.696 | 7 / 0 | 5.6 | No |
| 56087 |  CHEMBL384457 | C21H21ClN4O4S | 460.933 | 7 / 1 | 2.9 | Yes |
| 56089 |  CHEMBL217373 | C21H21ClN4O4S | 460.933 | 7 / 1 | 2.9 | Yes |
| 56242 |  CHEMBL259276 | C31H38N4O6 | 562.667 | 6 / 2 | 4.3 | No |
| 59336 |  CHEMBL227276 | C31H34N6O5 | 570.65 | 7 / 2 | 4.9 | No |
| 59728 |  CHEMBL217492 | C20H15ClN4O3S2 | 458.935 | 7 / 2 | 4.3 | Yes |
| 60026 |  CHEMBL214836 | C18H16Br2N4O3S2 | 560.279 | 7 / 1 | 4.6 | No |
| 60199 |  CHEMBL476531 | C32H29ClN4O2 | 537.06 | 4 / 0 | 6.9 | No |
| 60855 |  CHEMBL332263 | C41H54N6O7 | 742.918 | 7 / 7 | 4.9 | No |
| 60856 |  CHEMBL114774 | C41H54N6O7 | 742.918 | 7 / 7 | 4.9 | No |
| 61570 |  SCHEMBL604437 | C18H25N5O | 327.432 | 6 / 2 | 1.3 | Yes |
| 61868 |  CHEMBL399055 | C26H23ClN2O3 | 446.931 | 4 / 1 | 6.0 | No |
| 62625 |  CHEMBL215415 | C18H18ClN5O3S2 | 451.944 | 8 / 1 | 2.8 | Yes |
| 62791 |  CHEMBL476530 | C32H29FN4O2 | 520.608 | 5 / 0 | 6.4 | No |
| 62837 |  CHEMBL1161950 | C33H37F3N6O7 | 686.689 | 12 / 3 | N/A | No |
| 63508 |  CHEMBL516355 | C32H29FN4O2 | 520.608 | 5 / 0 | 6.4 | No |
| 63635 |  CHEMBL217053 | C18H13BrN2O4 | 401.216 | 5 / 1 | 3.5 | Yes |
| 65362 |  CHEMBL203530 | C29H36N4O4 | 504.631 | 5 / 1 | 5.2 | No |
| 66684 |  CCK-A Agonist 21 | C37H36N4O5 | 616.718 | 5 / 1 | 5.8 | No |
| 67751 |  CHEMBL249151 | C27H26N2O4 | 442.515 | 5 / 1 | 5.3 | No |
| 67888 |  CCK-A Agonist 41 | C35H33N5O4 | 587.68 | 5 / 1 | 5.6 | No |
| 69882 |  CHEMBL378388 | C28H34N4O4 | 490.604 | 5 / 2 | 4.9 | Yes |
| 70584 |  Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 | C50H59N9O10 | 946.075 | 11 / 11 | 0.8 | No |
| 70590 |  Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 | C50H59N9O10 | 946.075 | 11 / 11 | 0.8 | No |
| 71532 |  CHEMBL2017834 | C39H37N7O2 | 635.772 | 5 / 1 | 6.2 | No |
| 71949 |  CCK-A Agonist 31 | C35H32FN5O4 | 605.67 | 6 / 1 | 5.7 | No |
| 72451 |  CHEMBL292097 | C32H41N7O7 | 635.722 | 8 / 8 | -1.5 | No |
| 73838 |  CHEMBL410138 | C28H27N5O4 | 497.555 | 4 / 1 | 3.2 | Yes |
| 74401 |  CHEMBL264150 | C30H37N9O4 | 587.685 | 8 / 2 | 4.2 | No |
| 76452 |  CHEMBL217957 | C58H73N11O13 | 1132.29 | 14 / 13 | 2.2 | No |
| 76460 |  CHEMBL218600 | C58H73N11O13 | 1132.29 | 14 / 13 | 2.2 | No |
| 76746 |  CHEMBL215111 | C24H22N4O3S2 | 478.585 | 7 / 1 | 4.8 | Yes |
| 79724 |  CHEMBL387018 | C21H20BrN3O3S | 474.373 | 5 / 1 | 4.2 | Yes |
| 80338 |  CHEMBL479046 | C32H30N4O2 | 502.618 | 4 / 0 | 6.3 | No |
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