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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000683121
Molecular formula	C17H14N2O5S
IUPAC name	ethyl 2-[2-[(4-oxochromene-2-carbonyl)amino]-1,3-thiazol-4-yl]acetate
Molecular weight	358.368
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.1
Synonyms	361478-78-6 cid_3548924 MolPort-003-015-800 AC1MTDNS ethyl 2-[2-[(4-oxochromene-2-carbonyl)amino]-1,3-thiazol-4-yl]acetate SR-01000443341 2-[2-[(4-ketochromene-2-carbonyl)amino]thiazol-4-yl]acetic acid ethyl ester MCULE-1526238396 ZINC3892568 ethyl 2-(2-(4-oxo-4H-chromene-2-carboxamido)thiazol-4-yl)acetate Oprea1_597861 AKOS017104111 F0463-0247 SR-01000443341-1 2-[2-[[oxo-(4-oxo-1-benzopyran-2-yl)methyl]amino]-4-thiazolyl]acetic acid ethyl ester CHEMBL1371941 AB00137835-03 ethyl 2-[2-[(4-oxidanylidenechromen-2-yl)carbonylamino]-1,3-thiazol-4-yl]ethanoate SMR000322946 BDBM97107 HMS2684F04 SR-01000443341-3 [ Show all ]
Inchi Key	GHZHRMPDHBKSMK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14N2O5S/c1-2-23-15(21)7-10-9-25-17(18-10)19-16(22)14-8-12(20)11-5-3-4-6-13(11)24-14/h3-6,8-9H,2,7H2,1H3,(H,18,19,22)
PubChem CID	3548924
ChEMBL	CHEMBL1371941
IUPHAR	N/A
BindingDB	97107
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3825.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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