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Name | Beta-3 adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRB3 |
Synonym | ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR [ Show all ] |
Disease | Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome [ Show all ] |
Length | 408 |
Amino acid sequence | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS |
UniProt | P13945 |
Protein Data Bank | N/A |
GPCR-HGmod model | P13945 |
3D structure model | This predicted structure model is from GPCR-EXP P13945. |
BioLiP | N/A |
Therapeutic Target Database | T51408 |
ChEMBL | CHEMBL246 |
IUPHAR | 30 |
DrugBank | BE0001012, BE0004872 |
Name | CHEMBL469821 |
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Molecular formula | C28H34N2O4S |
IUPAC name | 4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-(2-methylpropyl)-N-methylsulfonylbenzamide |
Molecular weight | 494.65 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 4.7 |
Synonyms | BDBM50277531 SCHEMBL4584104 4''-(2-{[(2R)-2-Hydroxy-2-phenylethyl]amino}ethyl)-3-isobutyl-N-(methylsulfonyl)biphenyl-4-carboxamide Hydrochloride CHEMBL1186563 |
Inchi Key | FKGYWDPSUXSSQK-MHZLTWQESA-N |
Inchi ID | InChI=1S/C28H34N2O4S/c1-20(2)17-25-18-24(13-14-26(25)28(32)30-35(3,33)34)22-11-9-21(10-12-22)15-16-29-19-27(31)23-7-5-4-6-8-23/h4-14,18,20,27,29,31H,15-17,19H2,1-3H3,(H,30,32)/t27-/m0/s1 |
PubChem CID | 11340895 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50277531 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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EC50 | 0.46 nM | PMID19366244 | BindingDB |
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