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GPCR

NameGalanin receptor type 2
SpeciesHomo sapiens (Human)
GeneGALR2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A
Length387
Amino acid sequenceMNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProtO43603
Protein Data BankN/A
GPCR-HGmod modelO43603
3D structure modelThis predicted structure model is from GPCR-EXP O43603.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3176
IUPHAR244
DrugBankN/A

Ligand

NameCHEMBL1921999
Molecular formulaC24H26F3N5O2
IUPAC name2-N-cyclohexyl-6-N-(4-methoxyphenyl)-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4,6-triamine
Molecular weight473.5
Hydrogen bond acceptor10
Hydrogen bond donor3
XlogP7.2
SynonymsBDBM50358658
SCHEMBL10143574
Inchi KeyFEDUZLNTDOEBJT-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H26F3N5O2/c1-33-19-12-10-17(11-13-19)28-21-15-22(32-23(31-21)30-16-6-3-2-4-7-16)29-18-8-5-9-20(14-18)34-24(25,26)27/h5,8-16H,2-4,6-7H2,1H3,(H3,28,29,30,31,32)
PubChem CID57399457
ChEMBLCHEMBL1921999
IUPHARN/A
BindingDB50358658
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50550.0 nMPMID22018787BindingDB,ChEMBL
Inhibition<50.0 %PMID22018787ChEMBL

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