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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000675919
Molecular formula	C12H8F4N2O2S
IUPAC name	4-(4-fluorophenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
Molecular weight	320.262
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	2.5
Synonyms	4-(4-fluorophenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine cid_2987363 ST50636099 AKOS003395219 MCULE-6117419219 4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine SCHEMBL19805665 EU-0089240 STK340647 BDBM43524 4-(4-fluorophenyl)-2-mesyl-6-(trifluoromethyl)pyrimidine CHEMBL1375338 SMR000297077 AC1MGK68 HMS2589H09 ZINC215166 CCG-27092 MolPort-002-099-979 [ Show all ]
Inchi Key	FABYEEIARBZBHO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
PubChem CID	2987363
ChEMBL	CHEMBL1375338
IUPHAR	N/A
BindingDB	43524
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29916.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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