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Name | 5-hydroxytryptamine receptor 2A |
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Species | Rattus norvegicus (Rat) |
Gene | Htr2a |
Synonym | serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 471 |
Amino acid sequence | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV |
UniProt | P14842 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL322 |
IUPHAR | 6 |
DrugBank | N/A |
Name | spiperone |
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Molecular formula | C23H26FN3O2 |
IUPAC name | 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 395.478 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 3.0 |
Synonyms | LS-154780 36693-EP2371814A1 NCGC00015964-03 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one NCGC00015964-11 [ Show all ] |
Inchi Key | DKGZKTPJOSAWFA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) |
PubChem CID | 5265 |
ChEMBL | CHEMBL267930 |
IUPHAR | 3300, 99 |
BindingDB | 21397 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.3 nM | PMID8524985 | BindingDB |
Ki | 0.31 nM | PMID7582481 | BindingDB |
Ki | 0.33 nM | PMID7908055 | BindingDB |
Ki | 0.39 nM | PMID7984267 | BindingDB |
Ki | 0.4 nM | PMID1347569 | BindingDB |
Ki | 0.42 nM | PMID9225287 | BindingDB |
Ki | 0.43 nM | PMID8301575 | BindingDB |
Ki | 0.5 nM | PMID6645787 | BindingDB |
Ki | 0.6 nM | PMID7984267, PMID9686407 | BindingDB |
Ki | 0.630957 - 1.0 nM | PMID11040033, PMID9655845 | IUPHAR |
Ki | 1.0 nM | PMID9214741 | BindingDB,ChEMBL |
Ki | 1.04 nM | PMID6645787 | BindingDB |
Ki | 1.24 nM | PMID6645787 | BindingDB |
Ki | 1.6 nM | PMID2795135 | BindingDB |
Ki | 1.8 nM | PMID9836624 | BindingDB,ChEMBL |
Ki | 1.99 nM | PMID7984267, PMID10611634 | BindingDB |
Ki | 3.98 nM | PMID7984267 | BindingDB |
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