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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS002156773
Molecular formula	C23H20FN5O2S
IUPAC name	4-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-2-pyridin-3-ylquinazoline
Molecular weight	449.504
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	3.3
Synonyms	AB00755236-06 NCGC00287735-01 CHEMBL1494017 ZINC13117401 920911-45-1 AKOS021972774 SMR001239275 4-[4-(4-fluorobenzenesulfonyl)piperazin-1-yl]-2-(pyridin-3-yl)quinazoline HMS3051P06 AB00755236-01 MolPort-004-179-077 Z31102959 4-{4-[(4-fluorophenyl)sulfonyl]piperazino}-2-(3-pyridyl)quinazoline MCULE-5749552167 [ Show all ]
Inchi Key	AIEZKTDMVNDTBE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20FN5O2S/c24-18-7-9-19(10-8-18)32(30,31)29-14-12-28(13-15-29)23-20-5-1-2-6-21(20)26-22(27-23)17-4-3-11-25-16-17/h1-11,16H,12-15H2
PubChem CID	16319239
ChEMBL	CHEMBL1494017
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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