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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	1,10-phenanthroline
Molecular formula	C12H8N2
IUPAC name	1,10-phenanthroline
Molecular weight	180.21
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	1.8
Synonyms	1,10-o-phenanthroline LS-284 1,10-Phenanthroline, Anhydrous NCGC00013043-02 22802-96-6 (hydrochloride) NCGC00013043-10 AC-18353 NCI4265 AKOS000281773 NSC203545 beta-phenanthroline P0221 CHEBI:44975 RP24170 Cyto5A5 SR-01000076093-1 EU-0100985 .beta.-Phenanthroline InChI=1/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8 Tox21_500985 ZINC164363 KS-000044UM 1,10-Phenanthroline (anhydrous) MFCD00011678 1,10-phenathroline NCGC00013043-05 NCGC00091201-03 ACMC-209nwd NCIStruc2_000199 ANW-35243 o-Phenanthrolin C00604 phen cid_1318 SC-23392 DSSTox_CID_5857 FT-0660636 1,10 CPhenanthroline anhydrous UNII-W4X6ZO7939 1,10-Fenanthrolin [Czech] Lopac0_000985 1,10-Phenanthroline, 99+% MolPort-000-884-337 2-phenanthroline NCGC00013043-08 AA-860/25004133 NCGC00259547-01 AJ-16122 NSC-203545 BC213577 orthophenanthroline CCG-38059 PHN CS-W004544 Solution forms containing 1,10-phenanthroline DTXSID1025857 HMS3371F11 Tox21_201998 WLN: T B666 CN NNJ 1,10-phenanthrolin M-5271 1,10-Phenanthroline,hydrochloride NCGC00013043-03 3829-86-5 (mono-hydrochloride) NCGC00091201-01 AC1L1B7N NCI60_003976 AN-13060 NSC4265 BR-27000 P0879 RTR-022535 DB02365 ST45051101 F3377-1129 011P678 J-610043 TR-022535 [1,10]-Phenanthroline KSC241K8T 1,10-Phenanthroline anhydrous MLS000069797 1.10-phenanthroline NCGC00013043-06 66-71-7 NCGC00091201-04 Activ-8 NSC 203545 ARONIS014409 o-phenanthroline C12H8N2 Phenanthroline CJ-02115 SCHEMBL8312 DSSTox_GSID_25857 HMS2234D03 1,10 phenanthroline STL069281 W-104740 1,10-Fenanthroline LP00985 1,10-Phenanthroline, >=99% NCGC00013043 21532-74-1 (monoperchlorate) NCGC00013043-09 AB1003025 NCGC00261670-01 AK-27000 NSC-4265 BDBM50092158 P 9375 CCRIS 4855 pyridino[3,2-h]quinoline CU-00000000156-1 SR-01000076093 EINECS 200-629-2 (OP)2Cu(I) I14-1787 Tox21_303111 ZB008111 K835 MCULE-2911225521 1,10-phenantroline NCGC00013043-04 4,5-diazaphenanthrene NCGC00091201-02 AC1Q2ARN NCIStruc1_000192 AN-21862 O-PHE C-1044 P1826 CHEMBL415879 SBB089685 DGEZNRSVGBDHLK-UHFFFAOYSA-N FT-0606035 1,1 0-phenanthroline TRA0078227 [1,10]phenanthroline Lopac-P-9375 1,10-Phenanthroline in combination with isoniazid and rifampicin MLS002701886 16561-55-0 (zinc salt) NCGC00013043-07 A835532 NCGC00257123-01 Activ-8 in hexylene glycol NSC 4265 AS-14043 Opera_ID_711 CAS-66-71-7 phenantroline copper phenanthroline SMR000058190 DSSTox_RID_77950 HMS3263E11 1,10-Fenanthrolin TL8004718 W4X6ZO7939 [ Show all ]
Inchi Key	DGEZNRSVGBDHLK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H
PubChem CID	1318
ChEMBL	CHEMBL415879
IUPHAR	N/A
BindingDB	50092158
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<42000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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