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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS002164468
Molecular formula	C20H28N6OS
IUPAC name	2-(1-cyclopropyltetrazol-5-yl)sulfanyl-1-[4-[(4-propan-2-ylphenyl)methyl]piperazin-1-yl]ethanone
Molecular weight	400.545
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.8
Synonyms	2-[(1-cyclopropyl-1,2,3,4-tetrazol-5-yl)sulfanyl]-1-[4-[(4-propan-2-ylphenyl)methyl]piperazin-1-yl]ethanone BDBM97163 SMR001246841 2-[(1-cyclopropyltetrazol-5-yl)thio]-1-[4-(4-isopropylbenzyl)piperazino]ethanone cid_9261962 AC1PNMQE 2-[(1-cyclopropyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]-1-(4-{[4-(propan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one Z151960050 879354-91-3 HMS3076F04 2-(1-cyclopropyltetrazol-5-yl)sulfanyl-1-[4-[(4-propan-2-ylphenyl)methyl]piperazin-1-yl]ethanone AKOS033394573 MolPort-005-516-404 2-[(1-cyclopropyl-5-tetrazolyl)thio]-1-[4-[(4-propan-2-ylphenyl)methyl]-1-piperazinyl]ethanone CHEMBL1357535 ZINC23731397 MCULE-5669073000 [ Show all ]
Inchi Key	DBQUNKYLWWHSNA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H28N6OS/c1-15(2)17-5-3-16(4-6-17)13-24-9-11-25(12-10-24)19(27)14-28-20-21-22-23-26(20)18-7-8-18/h3-6,15,18H,7-14H2,1-2H3
PubChem CID	9261962
ChEMBL	CHEMBL1357535
IUPHAR	N/A
BindingDB	97163
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1341.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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