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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	CHEMBL3883495
Molecular formula	C23H23Cl2FN4O2
IUPAC name	2-(3,4-dichlorophenyl)-6-[3-[4-(4-fluorophenyl)piperazin-1-yl]propoxy]pyridazin-3-one
Molecular weight	477.361
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.8
Synonyms	BDBM50208483
Inchi Key	ANAAEVFNRAOJLN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23Cl2FN4O2/c24-20-7-6-19(16-21(20)25)30-23(31)9-8-22(27-30)32-15-1-10-28-11-13-29(14-12-28)18-4-2-17(26)3-5-18/h2-9,16H,1,10-15H2
PubChem CID	134131278
ChEMBL	CHEMBL3883495
IUPHAR	N/A
BindingDB	50208483
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	64.5 nM	PMID27639363	ChEMBL
Ki	65.0 nM	PMID27639363	BindingDB

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