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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	CHEMBL1922012
Molecular formula	C23H26FN5O
IUPAC name	4-N-(4-fluoro-2-methylphenyl)-2-N-(4-methoxyphenyl)-6-piperidin-1-ylpyrimidine-2,4-diamine
Molecular weight	407.493
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.7
Synonyms	BDBM50358682 SCHEMBL10144352
Inchi Key	CZOLAOWNMUBTGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H26FN5O/c1-16-14-17(24)6-11-20(16)26-21-15-22(29-12-4-3-5-13-29)28-23(27-21)25-18-7-9-19(30-2)10-8-18/h6-11,14-15H,3-5,12-13H2,1-2H3,(H2,25,26,27,28)
PubChem CID	57395995
ChEMBL	CHEMBL1922012
IUPHAR	N/A
BindingDB	50358682
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	980.0 nM	PMID22018787	BindingDB,ChEMBL
Inhibition	<50.0 %	PMID22018787	ChEMBL

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