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Name | Histamine H4 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL3805361 |
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Molecular formula | C19H24N6S |
IUPAC name | 1-cyano-2-[[(1S,3S)-3-(1H-imidazol-5-yl)cyclopentyl]methyl]-3-(2-phenylsulfanylethyl)guanidine |
Molecular weight | 368.503 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 2.8 |
Synonyms | BDBM50170126 J3.639.707A 1-[[(1S,3S)-3-(1H-Imidazole-4-yl)cyclopentane-1-yl]methyl]-2-cyano-3-[2-(phenylthio)ethyl]guanidine |
Inchi Key | MMZLYDNVAYWZLR-HOTGVXAUSA-N |
Inchi ID | InChI=1S/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/m0/s1 |
PubChem CID | 127052293 |
ChEMBL | CHEMBL3805361 |
IUPHAR | N/A |
BindingDB | 50170126 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 11.0 nM | PMID27007611 | BindingDB,ChEMBL |
EC50 | 14.0 nM | PMID27007611 | BindingDB,ChEMBL |
EC50 | 25.0 nM | PMID27007611 | BindingDB,ChEMBL |
Intrinsic activity | 0.75 - | PMID27007611 | ChEMBL |
Intrinsic activity | 0.9 - | PMID27007611 | ChEMBL |
Intrinsic activity | 1.0 - | PMID27007611 | ChEMBL |
Ki | 22.0 nM | PMID27007611 | BindingDB,ChEMBL |
Ki | 99.0 nM | PMID27007611 | BindingDB,ChEMBL |
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