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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS002253020
Molecular formula	C20H18N2O3
IUPAC name	2-[4-(4-methylphenoxy)phenoxy]-N-pyridin-4-ylacetamide
Molecular weight	334.375
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.6
Synonyms	2-[4-(4-methylphenoxy)phenoxy]-N-pyridin-4-yl-ethanamide CHEMBL1705098 SMR001315349 HMS1396N14 Z56786030 2-[4-(4-methylphenoxy)phenoxy]-N-(4-pyridyl)acetamide BDBM94062 MolPort-003-996-314 2-[4-(4-methylphenoxy)phenoxy]-N-pyridin-4-ylacetamide cid_2318546 SR-01000867704 AC1M4YYZ MCULE-2815129491 ZINC12524765 2-[4-(4-methylphenoxy)phenoxy]-N-(pyridin-4-yl)acetamide Oprea1_802423 328034-02-2 Enamine_001004 SR-01000867704-2 AKOS034454600 [ Show all ]
Inchi Key	CORMWJFTMXSPFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18N2O3/c1-15-2-4-18(5-3-15)25-19-8-6-17(7-9-19)24-14-20(23)22-16-10-12-21-13-11-16/h2-13H,14H2,1H3,(H,21,22,23)
PubChem CID	2318546
ChEMBL	CHEMBL1705098
IUPHAR	N/A
BindingDB	94062
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	158.36 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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