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GPCR

NameC-C chemokine receptor type 3
SpeciesRattus norvegicus (Rat)
GeneCcr3
SynonymCKR3
chemokine (C-C motif) receptor 3
CD193
CCR3
CCR-3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF
UniProtO54814
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3928
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3355945
Molecular formulaC25H31FN2S
IUPAC name2-ethyl-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-6-methyl-1H-indole
Molecular weight410.595
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP6.5
SynonymsBDBM50041186
Inchi KeyTVSACSZJCZUBIY-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H31FN2S/c1-3-23-25(22-10-5-18(2)17-24(22)27-23)19-11-14-28(15-12-19)13-4-16-29-21-8-6-20(26)7-9-21/h5-10,17,19,27H,3-4,11-16H2,1-2H3
PubChem CID118721195
ChEMBLCHEMBL3355945
IUPHARN/A
BindingDB50041186
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki420.0 nMPMID25497216BindingDB,ChEMBL

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