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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Homo sapiens (Human)
Gene	CRHR2
Synonym	CRH-R2 CRH-R-2 CRFR2beta CRFR2alpha CRFR2 CRFR-2 CRF2 receptor CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 [ Show all ]
Disease	Generalized anxiety disorder Anxiety disorder Congestive heart failure Eating disorders stimulate food consumption anxiety
Length	411
Amino acid sequence	MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q13324
Protein Data Bank	N/A
GPCR-HGmod model	Q13324
3D structure model	This predicted structure model is from GPCR-EXP Q13324.
BioLiP	N/A
Therapeutic Target Database	T11011
ChEMBL	CHEMBL4069
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL295563
Molecular formula	C22H30N4O2
IUPAC name	3-(2,4-dimethoxyphenyl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Molecular weight	382.508
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.9
Synonyms	BDBM50087707 N,N-Dipropyl-2,5-dimethyl-3-(2,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-7-amine [3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine [3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine
Inchi Key	YGIHMRSIPWHSFR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H30N4O2/c1-7-11-25(12-8-2)20-13-15(3)23-22-21(16(4)24-26(20)22)18-10-9-17(27-5)14-19(18)28-6/h9-10,13-14H,7-8,11-12H2,1-6H3
PubChem CID	44290322
ChEMBL	CHEMBL295563
IUPHAR	N/A
BindingDB	50087707
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID10794681	BindingDB,ChEMBL

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