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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	Dirigestran
Molecular formula	C55H75N17O13
IUPAC name	N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	1182.31
Hydrogen bond acceptor	15
Hydrogen bond donor	16
XlogP	-2.4
Synonyms	Hypocrine LH-RH Lutal Luteinizing hormone-releasing factor (sheep) Mammalian LH-RH 6918-09-8 Ovine LH-RH CHEMBL1981292 Synthetic Gn-RH Fertagyl Synthetic LH-releasing hormone/FSH-releasing hormone Gonadoliberin I Gonadoreline L000690 LHFSHRH Luteinizing hormone releasing hormone Luteinizing hormone-releasing hormone (swin) N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-azanyl-2-oxidanylidene-ethyl)carbamoyl]pyrrolidin-1-yl]-5-[bis(azanyl)methylideneamino]-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]amino]-3-(4-hydroxyphenyl)-1-o AC1L1VXF pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 DB00644 Synthetic gonadotropin-releasing hormone FSH-Releasing Hormone Synthetic LH-RH/FSH-RH Gonadorelin (INN) Gonadotropin, luteinizing hormone-releasing hormone, synthetic LH-Releasing factor (pig) LS-174422 Luteinizing hormone-releasing factor (pig) Mammalian GnRH NCGC00182043-01 C07607 Relisorm l EINECS 251-553-1 Synthetic LH-releasing factor Gn-RH Gonadorelina HOE 471 I06-0360 LH-RH (swine) Lutamin Luteinizing hormone-releasing factor (swine) MammalianGnRH 9034-40-6 Porchine LH-RH D04ODH Synthetic gonadoliberin Fertagyl (TN) Synthetic LH-RF Gonadoliberin, Luliberin Gonadorelinum LFRH LHRH Luteinizing hormone releasing hormone human Lutrefact N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropa AN-7551 Relefact Synthetic LH-FSH releasing hormone FT-0628048 Synthetic LRF Gonadorelin decapeptide Gonadotropin-releasing hormone Human LH-RH LH-Releasing hormone (porcine) Luforan Luteinizing hormone-releasing factor (rat) Mammalian gonadotropin-releasing hormone Ovine gonadotropin-releasing hormone C55H75N17O13 Synthetic decapeptide FSH/LH-RH Factrel Synthetic LH-releasing hormone GnRH-I Gonadorelina [INN-Spanish] Kryptocur LHFSH Releasing Hormone LUTEINIZING HORMONE Luteinizing hormone-releasing hormone MT-BT A821811 Porcine LH-releasing factor Synthetic gonadotropic hormone-releasing hormone Follicle-stimulating hormone-releasing factor (pig) Synthetic LH-RH GONADORELIN Gonadorelinum [INN-Latin] LH-FSH Releasing Hormone LHRH, human Luteinizing hormone-releasing factor (human) Lutrepulse KIT N-[2-[[2-[[2-[[2-[[2-[[1-[[1-[2-[(2-amino-2-oxo-ethyl)carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3 AY-24031 Relisorm Dirigestran Spofa Synthetic LH-FSH-RH Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl- XLXSAKCOAKORKW-UHFFFAOYSA-N Gonadorelin [INN:BAN] Gonadotropin-releasing hormone I [ Show all ]
Inchi Key	XLXSAKCOAKORKW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
PubChem CID	36523
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00644
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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