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GPCR

NameG-protein coupled receptor 4
SpeciesHomo sapiens (Human)
GeneGPR4
SynonymG-protein coupled receptor 19
GPR19
GPR4
DiseaseN/A
Length362
Amino acid sequenceMGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProtP46093
Protein Data BankN/A
GPCR-HGmod modelP46093
3D structure modelThis predicted structure model is from GPCR-EXP P46093.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3638324
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3675727
Molecular formulaC33H51N5O2Si
IUPAC name(2R)-1-[tert-butyl(dimethyl)silyl]oxy-3-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]propan-2-ol
Molecular weight577.889
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogPNone
SynonymsUS8748435, 17
BDBM123492
Inchi KeyWCFXFXUDOPZAGD-WBKPCLEFSA-N
Inchi IDInChI=1S/C33H51N5O2Si/c1-9-31-30(32-34-25(2)21-26(3)38(32)35-31)22-28-14-12-27(13-15-28)11-10-16-36-17-19-37(20-18-36)23-29(39)24-40-41(7,8)33(4,5)6/h10-15,21,29,39H,9,16-20,22-24H2,1-8H3/b11-10+/t29-/m1/s1
PubChem CID86766088
ChEMBLCHEMBL3675727
IUPHARN/A
BindingDB123492
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5030.0 nM, NoneBindingDB,ChEMBL

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