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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	Lysergide
Molecular formula	C20H25N3O
IUPAC name	(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	323.44
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	(8alpha)-N,N-Diethyl-6-Methyl-9,10-Didehydroergoline-8-Carboxamide N,N-Diethyl-(+)-Lysergamide 752-EP2308839A1 Cupcakes 6482-EP1441224A2 Orange Wedges 752-EP2308871A1 DB04829 752-EP2270006A1 Pearly gates [Street Name] 752-EP2314571A2 DSSTox_GSID_23231 752-EP2272973A1 Strawberry Fields 752-EP2371798A1 Ergoline-8beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- 752-EP2284162A2 UNII-8NA5SWF92O 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-beta-carboxamide Hawk 752-EP2289885A1 Yellows BDBM21342 Lisergide [DCIT] 752-EP2295407A1 Blue Star LSD (Lysergic Acid Diethylamide;Lysergide) 752-EP2298763A1 CHEMBL263881 Lucy in the Sky with Diamonds 752-EP2301928A1 Lysergidum 752-EP2305652A2 752-EP2305673A1 N,N-Diethyllysergamide 752-EP2308849A1 d-Lysergic acid dethylamide 6482-EP2311802A1 PDSP1_001431 752-EP2311825A1 Dextrolysergic Acid diethylamide 752-EP2272537A2 Royal blue 752-EP2316470A2 EINECS 200-033-2 752-EP2275417A2 The Hawk 752-EP2374786A1 Frogs 752-EP2284179A2 Wedding Bells Acid Acid [Street Name] Heavenly Blue [Street Name] 752-EP2292613A1 [N-methyl-3H]LSD Big F LS-64351 752-EP2298731A1 C07542 LSD solution, 25 mug/mL in acetonitrile, ampule of 1 mL, certified reference material 752-EP2298772A1 Chief Lysergaure diethylamid 752-EP2301937A1 (+)-LSD Lysergsaeurediethylamid (6aR,9R)-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide Mellow Yellow 752-EP2305686A1 Cubes 50-37-3 Orange Mushroom 752-EP2308867A2 D0M7LV 752-EP2269986A1 PDSP2_001524 752-EP2311842A2 Domes 752-EP2272842A1 SCHEMBL113755 752-EP2316833A1 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)- 752-EP2281812A1 Trippers 7LD Greenies 752-EP2287155A1 White Light Bart Simpson Instant Zen 752-EP2295402A2 Blue Cheer LSD (Lysergic Acid Diethylamide) 0.025 mg/ml in Acetonitrile 752-EP2298745A1 CHEBI:6605 LSD-25 752-EP2301627A1 752-EP2305648A1 (8beta)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide 752-EP2308847A1 D-Lsd 6482-EP2311494A1 Owsley 752-EP2308873A1 DEA No. 7315 752-EP2270014A1 Purple Haze 752-EP2314581A1 DSSTox_RID_76934 752-EP2275403A1 Sugar Lump 752-EP2371800A1 Fifty 752-EP2284163A2 VAYOSLLFUXYJDT-RDTXWAMCSA-N 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide Haze 752-EP2292228A1 ZINC96903803 BDBM50241702 Lisergido 752-EP2295410A1 BRN 0094179 LSD 25 752-EP2298767A1 CHEMBL463207 Lysergamid 752-EP2301929A1 Lysergidum [INN-Latin] 752-EP2305663A1 752-EP2305674A1 NCGC00168265-01 752-EP2308850A1 D-Lysergic acid diethylamide 6482-EP2311803A1 PDSP1_001540 752-EP2311829A1 Diethylamid kyseliny lysergove 752-EP2272822A1 Royal Blue [Street Name] 752-EP2316831A1 Ergoline-8-beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- 752-EP2277866A1 Tox21_112872 752-EP2374787A1 FT-0670891 752-EP2286811A1 Wedding bells [Street Name] AKOS028112397 HSDB 3920 752-EP2292619A1 Blotter Acid LSD 752-EP2298735A1 California Sunshine LSD,(+) 752-EP2298777A2 Chocolate Chips LYSERGIC ACID DIETHYLAMIDE 752-EP2305033A1 (+)-Lysergic acid diethylamide Lysergsauerediaethylamid (6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide Microdots 752-EP2308838A1 Cubes [Street Name] Orange Sunshine 752-EP2308870A2 752-EP2270004A1 Pearly gates 752-EP2311850A1 DSSTox_CID_3231 752-EP2272972A1 Spoonies 752-EP2371797A1 Ergoline-8b-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- (8CI) 752-EP2282982A1 Ubergluben 8NA5SWF92O GTPL17 752-EP2289868A1 Window Pane Bartman Lisergide 752-EP2295406A1 Blue Mist LSD (Lysergic Acid Diethylamide) 1.0 mg/ml in Acetonitrile 752-EP2298761A1 LSD-25, lysergidD 752-EP2301918A1 Lysergide [INN:BAN:DCF] 752-EP2305650A1 752-EP2305666A1 (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide N,N-Diethyl-D-lysergamide 752-EP2308848A1 D-LSD-25 6482-EP2311801A1 Paper Acid 752-EP2311808A1 Delysid 752-EP2270016A1 Purple Microdot 752-EP2314587A1 DTXSID1023231 752-EP2275411A2 Sunshine 752-EP2371804A1 Flats 752-EP2284178A2 Wedding bells AC1L1L2W Heavenly Blue 752-EP2292589A1 [3H]-LSD Beast Lisergido [INN-Spanish] 752-EP2295411A1 Brown Dots LSD solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material 752-EP2298770A1 Cherry Top Lysergamide, N,N-diethyl- 752-EP2301935A1 Lysergsaeurediaethylamid Mean Green 752-EP2305685A1 Contact Lens 4-25-00-00939 (Beilstein Handbook Reference) NCGC00168265-02 752-EP2308861A1 D-Lysergic acid N,N-diethylamide 6482-EP2371814A1 PDSP2_001415 752-EP2311834A1 Diethylamid kyseliny lysergove [Czech] 752-EP2272834A1 Scapes 752-EP2316832A1 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8b)- 752-EP2277872A1 Tox21_113508 752-EP2377849A2 Gelatin Chips 752-EP2287153A1 Wedges Barrels Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv. 752-EP2292624A1 Blue Acid LSD (alkaloid) 752-EP2298736A1 CAS-50-37-3 LSD,l- 752-EP2298783A1 Clearlight Lysergic acid diethylamide-25 752-EP2305640A2 (4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide [ Show all ]
Inchi Key	VAYOSLLFUXYJDT-RDTXWAMCSA-N
Inchi ID	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
PubChem CID	5761
ChEMBL	CHEMBL263881
IUPHAR	17
BindingDB	21342, 50241702
DrugBank	DB04829
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	9.0 nM	PMID12213075	BindingDB,ChEMBL
Ki	>10.0 nM	PMID12825922	BindingDB,ChEMBL

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