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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	CHEMBL364950
Molecular formula	C20H32N3O3PS
IUPAC name	1-dihydroxyphosphinothioyloxy-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propan-2-amine
Molecular weight	425.528
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	4.8
Synonyms	BDBM50169453 SCHEMBL3925968 CHEMBL1184707 Thiophosphoric acid 2-amino-2-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-propyl ester; TFA
Inchi Key	BMWHKUCAPSSVAZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H32N3O3PS/c1-3-4-5-6-7-8-9-16-10-12-17(13-11-16)18-14-22-19(23-18)20(2,21)15-26-27(24,25)28/h10-14H,3-9,15,21H2,1-2H3,(H,22,23)(H2,24,25,28)
PubChem CID	44398012
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50169453
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	170.0 nM	PMID15982878	BindingDB

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