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Name | 5-hydroxytryptamine receptor 7 |
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Species | Rattus norvegicus (Rat) |
Gene | Htr7 |
Synonym | GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 448 |
Amino acid sequence | MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT |
UniProt | P32305 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3223 |
IUPHAR | 12 |
DrugBank | N/A |
Name | CHEMBL363466 |
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Molecular formula | C20H25NO2 |
IUPAC name | (2S)-5-(2,6-dimethoxyphenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine |
Molecular weight | 311.425 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 4.2 |
Synonyms | (3S)-3alpha-(Dimethylamino)-8-(2,6-dimethoxyphenyl)tetralin BDBM50150673 |
Inchi Key | BFHVQDBLFZYJPG-HNNXBMFYSA-N |
Inchi ID | InChI=1S/C20H25NO2/c1-21(2)15-11-12-16-14(13-15)7-5-8-17(16)20-18(22-3)9-6-10-19(20)23-4/h5-10,15H,11-13H2,1-4H3/t15-/m0/s1 |
PubChem CID | 10064052 |
ChEMBL | CHEMBL363466 |
IUPHAR | N/A |
BindingDB | 50150673 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Efficacy | >10.0 % | PMID15267230 | ChEMBL |
Ki | 2.55 nM | PMID15267230 | BindingDB,ChEMBL |
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