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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000390375
Molecular formula	C17H18Cl2N4O3
IUPAC name	2-(4,5-dichloro-6-oxopyridazin-1-yl)-N-[2-(2-ethylanilino)-2-oxoethyl]-N-methylacetamide
Molecular weight	397.256
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.4
Synonyms	2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]-N-[2-[(2-ethylphenyl)amino]-2-oxidanylidene-ethyl]-N-methyl-ethanamide cid_2585250 AC1M9L9R 2-(4,5-dichloro-6-oxopyridazin-1-yl)-N-[2-(2-ethylanilino)-2-oxoethyl]-N-methylacetamide Z19024590 HMS2538G24 2-(4,5-dichloro-6-keto-pyridazin-1-yl)-N-[2-(2-ethylanilino)-2-keto-ethyl]-N-methyl-acetamide AKOS033655360 MolPort-005-531-827 2-[2-(4,5-dichloro-6-oxo-1,6-dihydropyridazin-1-yl)-N-methylacetamido]-N-(2-ethylphenyl)acetamide CHEMBL1374788 ZINC3464950 923799-20-6 MCULE-1395490520 2-(4,5-dichloro-6-oxo-1-pyridazinyl)-N-[2-(2-ethylanilino)-2-oxoethyl]-N-methylacetamide BDBM42061 SMR000255342 [ Show all ]
Inchi Key	MRFCCGDBEJIXFA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18Cl2N4O3/c1-3-11-6-4-5-7-13(11)21-14(24)9-22(2)15(25)10-23-17(26)16(19)12(18)8-20-23/h4-8H,3,9-10H2,1-2H3,(H,21,24)
PubChem CID	2585250
ChEMBL	CHEMBL1374788
IUPHAR	N/A
BindingDB	42061
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7616.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	17100.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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