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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL2372834
Molecular formula	C21H30N6O6
IUPAC name	(5S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3,8,14-trioxo-1,4,9-triazacyclotetradecane-5-carboxamide
Molecular weight	462.507
Hydrogen bond acceptor	7
Hydrogen bond donor	7
XlogP	-1.9
Synonyms	BDBM50452204
Inchi Key	BDLXRHXTYUQFLN-JYJNAYRXSA-N
Inchi ID	InChI=1S/C21H30N6O6/c22-14(10-12-3-5-13(28)6-4-12)20(32)27-16-2-1-9-24-17(29)8-7-15(19(23)31)26-18(30)11-25-21(16)33/h3-6,14-16,28H,1-2,7-11,22H2,(H2,23,31)(H,24,29)(H,25,33)(H,26,30)(H,27,32)/t14-,15-,16-/m0/s1
PubChem CID	73356350
ChEMBL	CHEMBL2372834
IUPHAR	N/A
BindingDB	50452204
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1760.0 nM	PMID2999401	BindingDB,ChEMBL
Potency ratio	0.0053 -	PMID2999401	ChEMBL

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