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GPCR

NameGalanin receptor type 2
SpeciesHomo sapiens (Human)
GeneGALR2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A
Length387
Amino acid sequenceMNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProtO43603
Protein Data BankN/A
GPCR-HGmod modelO43603
3D structure modelThis predicted structure model is from GPCR-EXP O43603.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3176
IUPHAR244
DrugBankN/A

Ligand

NameCHEMBL1922021
Molecular formulaC25H30FN5O2
IUPAC name6-N-(cyclohexylmethyl)-4-N-(3-fluoro-4-methoxyphenyl)-2-N-(4-methoxyphenyl)pyrimidine-2,4,6-triamine
Molecular weight451.546
Hydrogen bond acceptor8
Hydrogen bond donor3
XlogP6.7
SynonymsSCHEMBL10143485
BDBM50358669
Inchi KeyBDISGJJDTGNEDY-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H30FN5O2/c1-32-20-11-8-18(9-12-20)29-25-30-23(27-16-17-6-4-3-5-7-17)15-24(31-25)28-19-10-13-22(33-2)21(26)14-19/h8-15,17H,3-7,16H2,1-2H3,(H3,27,28,29,30,31)
PubChem CID57401226
ChEMBLCHEMBL1922021
IUPHARN/A
BindingDB50358669
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<50.0 %PMID22018787ChEMBL

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