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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	MK-0354
Molecular formula	C7H8N6
IUPAC name	3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight	176.183
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.2
Synonyms	1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole 4U62D8JYIQ HY-13008 SCHEMBL1875705 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole Cyclopenta(C)pyrazole, 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)- MK 0354 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole BCP18112 NCGC00263122-01 1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole(MK-0354) 5-{1H,4H,5H,6H-CYCLOPENTA[C]PYRAZOL-3-YL}-1H-1,2,3,4-TETRAZOLE CHEMBL456145 KB-78878 UNII-4U62D8JYIQ 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole 851776-28-8 D0A5MR 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole BDBM50273099 GTPL5784 NCGC00263122-02 1,4,5,6-tetrahydro-3-(2H-tetrazol-5-yl)Cyclopentapyrazole CS-4589 LTQYSJKGRPGMPO-UHFFFAOYSA-N ZINC38312374 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopentapyrazole AKOS030526928 DA-02747 MolPort-009-683-033 [ Show all ]
Inchi Key	LTQYSJKGRPGMPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
PubChem CID	11159621
ChEMBL	CHEMBL456145
IUPHAR	5784
BindingDB	50273099
DrugBank	DB05939
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	286.0 nM	PMID20363624, PMID22435740	BindingDB,ChEMBL
EC50	1650.0 nM	PMID18665582	BindingDB,IUPHAR,ChEMBL
EC50	2300.0 nM	PMID18665582	BindingDB,ChEMBL
Efficacy	59.0 %	PMID18665582	ChEMBL
Efficacy	72.0 %	PMID18665582	ChEMBL
Efficacy	96.0 %	PMID20363624, PMID22435740	ChEMBL
IC50	1500.0 nM	PMID19307116, PMID20615702	BindingDB,ChEMBL
Ki	505.0 nM	PMID18665582	BindingDB,ChEMBL

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