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GPCR

NameGalanin receptor type 1
SpeciesHomo sapiens (Human)
GeneGALR1
SynonymGAL1-R
GALNR
GALNR1
GALR-1
GAL1 receptor
DiseaseEpileptic seizures
Length349
Amino acid sequenceMELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProtP47211
Protein Data BankN/A
GPCR-HGmod modelP47211
3D structure modelThis predicted structure model is from GPCR-EXP P47211.
BioLiPN/A
Therapeutic Target DatabaseT78581
ChEMBLCHEMBL4894
IUPHAR243
DrugBankN/A

Ligand

NameCHEMBL1921987
Molecular formulaC22H22F3N5O
IUPAC name6-N-phenyl-2-piperidin-1-yl-4-N-[4-(trifluoromethoxy)phenyl]pyrimidine-4,6-diamine
Molecular weight429.447
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP6.4
SynonymsSCHEMBL10143797
Inchi KeyLTIAXVRWYFVSBA-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H22F3N5O/c23-22(24,25)31-18-11-9-17(10-12-18)27-20-15-19(26-16-7-3-1-4-8-16)28-21(29-20)30-13-5-2-6-14-30/h1,3-4,7-12,15H,2,5-6,13-14H2,(H2,26,27,28,29)
PubChem CID57392516
ChEMBLCHEMBL1921987
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition60.0 %PMID22018787ChEMBL

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