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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	SMR000235764
Molecular formula	C22H26N4O3S2
IUPAC name	4-(3,5-dimethylpiperidin-1-yl)sulfonyl-N'-(4-methyl-1,3-benzothiazol-2-yl)benzohydrazide
Molecular weight	458.595
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.1
Synonyms	HMS2246B11 BDBM41953 MolPort-003-038-241 4-(3,5-dimethylpiperidino)sulfonyl-N''-(4-methyl-1,3-benzothiazol-2-yl)benzohydrazide cid_12006167 851978-00-2 MCULE-3944872509 4-((3,5-dimethylpiperidin-1-yl)sulfonyl)-N'-(4-methylbenzo[d]thiazol-2-yl)benzohydrazide 4-[(3,5-dimethyl-1-piperidinyl)sulfonyl]-N''-(4-methyl-1,3-benzothiazol-2-yl)benzohydrazide F0642-0062 AKOS024590538 MLS000696648 4-(3,5-dimethylpiperidin-1-yl)sulfonyl-N''-(4-methyl-1,3-benzothiazol-2-yl)benzohydrazide CHEMBL1335491 [ Show all ]
Inchi Key	LBTRDZPKEWBWFH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N4O3S2/c1-14-11-15(2)13-26(12-14)31(28,29)18-9-7-17(8-10-18)21(27)24-25-22-23-20-16(3)5-4-6-19(20)30-22/h4-10,14-15H,11-13H2,1-3H3,(H,23,25)(H,24,27)
PubChem CID	12006167
ChEMBL	CHEMBL1335491
IUPHAR	N/A
BindingDB	41953
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<55700.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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