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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neurotensin receptor type 2
Species	Homo sapiens (Human)
Gene	NTSR2
Synonym	levocabastine-sensitive neurotensin receptor neurotensin receptor type 2 high-affinity levocabastine-sensitive neurotensin receptor NT2R NTR2 NTRL NTS2 receptor NT-R-2 [ Show all ]
Disease	N/A
Length	410
Amino acid sequence	METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
UniProt	O95665
Protein Data Bank	N/A
GPCR-HGmod model	O95665
3D structure model	This predicted structure model is from GPCR-EXP O95665.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2514
IUPHAR	310
DrugBank	N/A

Ligand

Name	CHEMBL2431133
Molecular formula	C27H28N4O3
IUPAC name	6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
Molecular weight	456.546
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	5.2
Synonyms	SMR003080911 MLS-0454791.0001 MolPort-000-830-985 AKOS005547874 STK613295 1-[4-(2-phenyl-6,7-dimethoxyquinazolin-4-yl)piperazinyl]-2-methoxybenzene 6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline MLS-0454791.0002 SCHEMBL15819136 BDBM50440763 ZINC8738178 489416-51-5 MCULE-6614147969 AC1NF8TN MLS004254797 [ Show all ]
Inchi Key	LAKZIVWNOULFMV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H28N4O3/c1-32-23-12-8-7-11-22(23)30-13-15-31(16-14-30)27-20-17-24(33-2)25(34-3)18-21(20)28-26(29-27)19-9-5-4-6-10-19/h4-12,17-18H,13-16H2,1-3H3
PubChem CID	4679731
ChEMBL	CHEMBL2431133
IUPHAR	N/A
BindingDB	50440763
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<80000.0 nM	PMID24611085	ChEMBL

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