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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	2-(2,5-dinitrothiophen-3-yl)pyrimidine
Molecular formula	C8H4N4O4S
IUPAC name	2-(2,5-dinitrothiophen-3-yl)pyrimidine
Molecular weight	252.204
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	1.9
Synonyms	2-{2,5-bisnitro-3-thienyl}pyrimidine HMS2611I20 AI-942/13331097 SMR000226688 2-(2,5-dinitro-3-thiophenyl)pyrimidine CHEMBL1400481 MLS000700336 BDBM34827 cid_3319616 AC1MOFRG REGID_for_CID_3319616 2-(2,5-dinitro-3-thienyl)pyrimidine [ Show all ]
Inchi Key	JHHSYNZURGGRBL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H4N4O4S/c13-11(14)6-4-5(8(17-6)12(15)16)7-9-2-1-3-10-7/h1-4H
PubChem CID	3319616
ChEMBL	CHEMBL1400481
IUPHAR	N/A
BindingDB	34827
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8959.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	9608.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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