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GPCR

Name	Neuropeptide FF receptor 1
Species	Homo sapiens (Human)
Gene	NPFFR1
Synonym	GnIH-R G protein-coupled receptor 147 OT7T022 NPFF1R1 NPFF1 receptor NPFF1 G-protein coupled receptor 147 GPR147 GnIH-R/RFRP-3 RFamide-related peptide receptor OT7T022 [ Show all ]
Disease	N/A
Length	430
Amino acid sequence	MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProt	Q9GZQ6
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ6
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5951
IUPHAR	300
DrugBank	N/A

Ligand

Name	311309-27-0
Molecular formula	C45H72N14O10
IUPAC name	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
Molecular weight	969.159
Hydrogen bond acceptor	12
Hydrogen bond donor	11
XlogP	-2.5
Synonyms	BDBM50029188 RFRP 3 (human) CHEMBL2165920 Neuropeptide VF (124-131) (human) BDBM86143 RFRP-3 L-Val-L-Pro-L-Asn-L-Leu-L-Pro-L-Gln-L-Arg-L-Phe-NH2 AKOS024458292 RFamide-related peptide 3 ZINC169289418 Neuropeptide NPVF [ Show all ]
Inchi Key	JFZCLMZUABKABL-GVCDGELBSA-N
Inchi ID	InChI=1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
PubChem CID	71451611
ChEMBL	CHEMBL2165920
IUPHAR	N/A
BindingDB	86143, 50029188
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Parameter	Value	Reference	Database source
EC50	1.7 nM	PMID22708927	BindingDB,ChEMBL
EC50	4.9 nM	PMID22708927	ChEMBL
EC50	7.7 nM	PMID22708927	ChEMBL
EC50	9.9 nM	PMID22708927	ChEMBL
EC50	16.0 nM	PMID22708927	ChEMBL
EC50	99.0 nM	PMID22708927	ChEMBL
EC50	314.0 nM	PMID22708927	ChEMBL
EC50	7876.0 nM	PMID22708927	ChEMBL
Emax	66.0 %	PMID22708927	ChEMBL
Emax	86.0 %	PMID22708927	ChEMBL
Emax	87.0 %	PMID22708927	ChEMBL
Emax	90.0 %	PMID22708927	ChEMBL
Emax	101.0 %	PMID22708927	ChEMBL
Emax	105.0 %	PMID22708927	ChEMBL
Ki	3.66 nM	PMID25268943	ChEMBL
Ki	3.7 nM	PMID25268943	BindingDB
Ratio EC50	2.0 -	PMID22708927	ChEMBL
Ratio EC50	5.0 -	PMID22708927	ChEMBL
Ratio EC50	6.0 -	PMID22708927	ChEMBL
Ratio EC50	9.0 -	PMID22708927	ChEMBL
Ratio EC50	58.0 -	PMID22708927	ChEMBL
Ratio EC50	184.0 -	PMID22708927	ChEMBL
Ratio EC50	4632.0 -	PMID22708927	ChEMBL

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