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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	CHEMBL1922015
Molecular formula	C22H24FN5O2
IUPAC name	4-N-(3-fluoro-4-methoxyphenyl)-2-N-(4-methoxyphenyl)-6-pyrrolidin-1-ylpyrimidine-2,4-diamine
Molecular weight	409.465
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	4.9
Synonyms	SCHEMBL10144179
Inchi Key	IYBJEGSSKQTJDP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H24FN5O2/c1-29-17-8-5-15(6-9-17)25-22-26-20(14-21(27-22)28-11-3-4-12-28)24-16-7-10-19(30-2)18(23)13-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H2,24,25,26,27)
PubChem CID	56643637
ChEMBL	CHEMBL1922015
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	<50.0 %	PMID22018787	ChEMBL

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