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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	CHEMBL1921901
Molecular formula	C23H27N5
IUPAC name	4-N-(2,5-dimethylphenyl)-6-N-phenyl-2-piperidin-1-ylpyrimidine-4,6-diamine
Molecular weight	373.504
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	6.0
Synonyms	BDBM50358663 SCHEMBL10143794
Inchi Key	ITHVQBNIKOJAOL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27N5/c1-17-11-12-18(2)20(15-17)25-22-16-21(24-19-9-5-3-6-10-19)26-23(27-22)28-13-7-4-8-14-28/h3,5-6,9-12,15-16H,4,7-8,13-14H2,1-2H3,(H2,24,25,26,27)
PubChem CID	57394303
ChEMBL	CHEMBL1921901
IUPHAR	N/A
BindingDB	50358663
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4570.0 nM	PMID22018787	BindingDB,ChEMBL
Inhibition	<50.0 %	PMID22018787	ChEMBL

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