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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	CHEMBL1921991
Molecular formula	C22H24FN5O
IUPAC name	4-N-(3-fluoro-4-methoxyphenyl)-6-N-phenyl-2-piperidin-1-ylpyrimidine-4,6-diamine
Molecular weight	393.466
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.3
Synonyms	BDBM50358651 SCHEMBL10143563
Inchi Key	IMGOBFAIFJMPOM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H24FN5O/c1-29-19-11-10-17(14-18(19)23)25-21-15-20(24-16-8-4-2-5-9-16)26-22(27-21)28-12-6-3-7-13-28/h2,4-5,8-11,14-15H,3,6-7,12-13H2,1H3,(H2,24,25,26,27)
PubChem CID	57395992
ChEMBL	CHEMBL1921991
IUPHAR	N/A
BindingDB	50358651
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8650.0 nM	PMID22018787	BindingDB,ChEMBL
Inhibition	<50.0 %	PMID22018787	ChEMBL

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