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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000998903
Molecular formula	C21H30FN3OS
IUPAC name	2-[1-(2,2-dimethylpropyl)-4-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]methyl]piperazin-2-yl]ethanol
Molecular weight	391.549
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.9
Synonyms	2-(1-(2,2-dimethylpropyl)-4-{[4-(4-fluorophenyl)-1,3-thiazol-2-yl]methyl}-2-piperazinyl)ethanol CHEMBL1720771 SR-01000171970-1 2-[1-(2,2-dimethylpropyl)-4-[[4-(4-fluorophenyl)-2-thiazolyl]methyl]-2-piperazinyl]ethanol MCULE-9026269767 BDBM97134 SMR000495716 2-(1-(2,2-dimethylpropyl)-4-{[4-(4-fluorophenyl)-1,3-thiazol-2-yl]methyl}piperazin-2-yl)ethanol cid_23723905 SR-01000171970-3 2-[4-[[4-(4-fluorophenyl)thiazol-2-yl]methyl]-1-neopentyl-piperazin-2-yl]ethanol SR-01000171970 2-[1-(2,2-dimethylpropyl)-4-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]methyl]piperazin-2-yl]ethanol HMS2842M18 MolPort-005-078-580 [ Show all ]
Inchi Key	GOUYUKOYEGKQEP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H30FN3OS/c1-21(2,3)15-25-10-9-24(12-18(25)8-11-26)13-20-23-19(14-27-20)16-4-6-17(22)7-5-16/h4-7,14,18,26H,8-13,15H2,1-3H3
PubChem CID	23723905
ChEMBL	CHEMBL1720771
IUPHAR	N/A
BindingDB	97134
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2829.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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