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BioLiP
Download all results in tab-seperated text for 41 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2gqg:A (2.4) BS01 1N1 2.7.10.2 GO:0004672 ... P00519 16740718 BindingDB: IC50=3.1nM, Kd=1.2nM, EC50=0.040000nM
    2 2gqg:B (2.4) BS01 1N1 2.7.10.2 GO:0004672 ... P00519 16740718 BindingDB: IC50=3.1nM, Kd=1.2nM, EC50=0.040000nM
    3 2y6o:A (1.543) BS01 1N1 2.7.10.1 GO:0004672 ... Q03137 22036717 MOAD: ic50=25nM
    PDBbind: -logKd/Ki=7.60, IC50=25nM
    4 2zva:A (2.6) BS01 1N1 2.7.10.2 GO:0004672 ... P25911 18984583 PDBbind: -logKd/Ki=7.96, IC50=11nM
    5 3g5d:A (2.2) BS01 1N1 2.7.10.2 GO:0004672 ... P00523 19462975 MOAD: Kd=11nM
    PDBbind: -logKd/Ki=7.96, Kd=11nM
    BindingDB: Kd=11nM, IC50=0.4nM
    6 3g5d:B (2.2) BS01 1N1 2.7.10.2 GO:0004672 ... P00523 19462975 MOAD: Kd=11nM
    BindingDB: Kd=11nM, IC50=0.4nM
    7 3k54:A (1.94) BS01 1N1 2.7.10.2 GO:0004672 ... Q06187 20052711 PDBbind: -logKd/Ki=9.00, Kd=1.0nM
    BindingDB: Kd=1.4nM, IC50=3.0nM
    8 3lfa:A (2.1) BS01 1N1 2.7.11.24 GO:0000077 ... Q16539 N/A BindingDB: Kd=230nM, IC50=100nM, EC50=470nM
    9 3oct:A (1.95) BS01 1N1 2.7.10.2 GO:0004672 ... Q06187 N/A PDBbind: -logKd/Ki=8.30, IC50=5nM
    BindingDB: Kd=1.4nM, IC50=3.0nM
    10 3oht:A (2.7) BS01 1N1 2.7.11.24 GO:0000165 ... A9UJZ9 21699901
    11 3oht:A (2.7) BS02 1N1 2.7.11.24 GO:0000165 ... A9UJZ9 21699901
    12 3oht:A (2.7) BS03 1N1 2.7.11.24 GO:0000165 ... A9UJZ9 21699901
    13 3oht:B (2.7) BS01 1N1 2.7.11.24 GO:0000165 ... A9UJZ9 21699901
    14 3oht:B (2.7) BS02 1N1 2.7.11.24 GO:0000165 ... A9UJZ9 21699901
    15 3oht:B (2.7) BS03 1N1 2.7.11.24 GO:0000165 ... A9UJZ9 21699901
    16 3qlg:A (2.75) BS01 1N1 2.7.10.2 GO:0004672 ... P00523 N/A BindingDB: Kd=11nM, IC50=0.4nM
    17 3qlg:B (2.75) BS01 1N1 2.7.10.2 GO:0004672 ... P00523 N/A BindingDB: Kd=11nM, IC50=0.4nM
    18 3sxr:A (2.4) BS01 1N1 2.7.10.2 GO:0004672 ... P51813 21883956 BindingDB: Kd=1.4nM
    19 3sxr:B (2.4) BS01 1N1 2.7.10.2 GO:0004672 ... P51813 21883956 BindingDB: Kd=1.4nM
    20 4qms:A (1.883) BS01 1N1 2.7.11.1 GO:0004672 ... Q9Y6E0 27135311 MOAD: ic50=7.4uM
    PDBbind: -logKd/Ki=5.13, IC50=7.4uM
    BindingDB: Kd=>10000nM
    21 4xey:A (2.891) BS01 1N1 2.7.10.2 GO:0004672 ... P00519 25779001 BindingDB: IC50=3.1nM, Kd=1.2nM, EC50=0.040000nM
    22 4xey:B (2.891) BS01 1N1 2.7.10.2 GO:0004672 ... P00519 25779001 BindingDB: IC50=3.1nM, Kd=1.2nM, EC50=0.040000nM
    23 4xli:A (2.5) BS01 1N1 2.7.10.2 GO:0004672 ... Q4JIM5 25849507 MOAD: Kd=0.17nM
    24 4xli:B (2.5) BS02 1N1 2.7.10.2 GO:0004672 ... Q4JIM5 25849507 MOAD: Kd=0.17nM
    25 5bvw:A (1.94) BS01 1N1 2.7.10.1 GO:0004672 ... Q08345 26191369 PDBbind: -logKd/Ki=8.82, IC50=0.0015uM
    BindingDB: Kd=0.69nM, IC50=4.8nM
    26 5h2u:A (2.24) BS01 1N1 2.7.10.2 GO:0004672 ... Q13882 27993680 MOAD: ic50=7nM
    PDBbind: -logKd/Ki=8.15, IC50=7nM
    BindingDB: Kd=7.8nM, IC50=5.3nM
    27 5h2u:B (2.24) BS01 1N1 2.7.10.2 GO:0004672 ... Q13882 27993680 MOAD: ic50=7nM
    BindingDB: Kd=7.8nM, IC50=5.3nM
    28 5h2u:C (2.24) BS01 1N1 2.7.10.2 GO:0004672 ... Q13882 27993680 MOAD: ic50=7nM
    BindingDB: Kd=7.8nM, IC50=5.3nM
    29 5h2u:D (2.24) BS01 1N1 2.7.10.2 GO:0004672 ... Q13882 27993680 MOAD: ic50=7nM
    BindingDB: Kd=7.8nM, IC50=5.3nM
    30 5i9y:A (1.228) BS01 1N1 2.7.10.1 GO:0004672 ... P29317 27768280 MOAD: Kd=2.8nM
    PDBbind: -logKd/Ki=8.55, Kd=2.8nM
    BindingDB: Kd=0.85nM, IC50=137nM
    31 5owr:A (2.3) BS01 1N1 2.7.11.1 GO:0004672 ... O94804 N/A BindingDB: Kd=1200nM
    32 5vcv:A (1.92) BS01 1N1 2.7.11.1 GO:0004672 ... Q99640 28792760 MOAD: Kd=150nM
    PDBbind: -logKd/Ki=6.82, Kd=150nM
    BindingDB: Kd=130nM, IC50=6.0nM, Ki=73nM
    33 6bsd:A (2.606) BS01 1N1 2.7.10.1 GO:0004672 ... Q08345 30612951 BindingDB: Kd=0.69nM, IC50=4.8nM
    34 6fnm:A (1.157) BS01 1N1 2.7.10.1 GO:0004672 ... P54760 29928781 BindingDB: Kd=0.34nM
    35 7erk:A (1.703) BS01 1N1 ? N/A P02766 34547896
    36 7erk:B (1.703) BS01 1N1 ? N/A P02766 34547896
    37 7n9g:A (2.2) BS02 1N1 2.7.10.2 GO:0004672 ... P00519 34774565
    38 7n9g:B (2.2) BS02 1N1 2.7.10.2 GO:0004672 ... P00519 34774565
    39 7n9g:C (2.2) BS02 1N1 2.7.10.2 GO:0004672 ... P00519 34774565
    40 8s9f:A (2.6) BS01 1N1 2.7.10.2 GO:0004672 ... P35991 38189455
    41 8s9f:B (2.6) BS01 1N1 2.7.10.2 GO:0004672 ... P35991 38189455
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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