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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	U 46619
Molecular formula	C21H34O4
IUPAC name	(Z)-7-[(1R,4S,5S,6R)-6-[(E,3S)-3-hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid
Molecular weight	350.499
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.9
Synonyms	11alpha,9alpha-epoxymethano-PGH2 9,11-Dideoxy-9alpha,11alpha-methanoepoxy PGF2alpha BML1-G04 GTPL1974 MolPort-019-939-222 U-46619 5-Heptenoic acid, 7-(6-(3-hydroxy-1-octenyl)-2-oxabicyclo(2.2.1)hept-5-yl)-, (1R-(1-alpha,4-alpha,5-beta(Z),6-alpha(1E,3S*)))- 9alpha,11alpha-Methanoepoxy-PGF2alpha HMS1989M16 NCGC00161291-03 [3H]U 46619 (Z)-7-[(1S,4R,5R,6S)-5-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid 9,11-dideoxy-9.alpha.,11.alpha.-methanoepoxyprostaglandin F2alpha AKOS024456866 D0Y6OL IDI1_034004 SMR000058897 9,11-Methanoepoxy PGH2 BRD-K18757346-001-02-9 HMS1361M16 NCGC00161291-01 U46619 (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid 9alpha-PGM CHEMBL521784 HMS2234N20 Opera_ID_380 [3H]U46619 11-9 EM 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a BDBM50292409 GTPL1888 MLS000028857 9a,11a-Methanoepoxy-15-hydroxyprosta-5,13-dienoic acid BSPBio_001534 HMS1791M16 NCGC00161291-02 ZINC8716754 (Z)-7-((1R,4S,5S,6R)-6-((S,E)-3-hydroxyoct-1-enyl)-2-oxabicyclo[2.2.1]heptan-5-yl)hept-5-enoic acid 56985-40-1 9salpha,11alpha-Methanoepoxy-PGF2alpha D03PLH HMS3402M16 SCHEMBL12272421 [ Show all ]
Inchi Key	LQANGKSBLPMBTJ-BRSNVKEHSA-N
Inchi ID	InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
PubChem CID	5311493
ChEMBL	CHEMBL521784
IUPHAR	1888, 1974
BindingDB	50292409
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
486867	Parathyroid hormone/parathyroid hormone-related peptide receptor	Q03431	PTH1R	Homo sapiens (Human)	593
554265	Prostacyclin receptor	P43119	PTGIR	Homo sapiens (Human)	386
554268	Prostaglandin D2 receptor	Q13258	PTGDR	Homo sapiens (Human)	359
554267	Prostaglandin D2 receptor 2	Q9Y5Y4	PTGDR2	Homo sapiens (Human)	395
554260	Prostaglandin E2 receptor EP1 subtype	P70597	Ptger1	Rattus norvegicus (Rat)	405
554264	Prostaglandin E2 receptor EP1 subtype	P34995	PTGER1	Homo sapiens (Human)	402
554257	Prostaglandin E2 receptor EP2 subtype	P43116	PTGER2	Homo sapiens (Human)	358
554266	Prostaglandin E2 receptor EP2 subtype	Q62928	Ptger2	Rattus norvegicus (Rat)	357
554258	Prostaglandin E2 receptor EP3 subtype	P43115	PTGER3	Homo sapiens (Human)	390
554263	Prostaglandin E2 receptor EP3 subtype	P34980	Ptger3	Rattus norvegicus (Rat)	365
554262	Prostaglandin E2 receptor EP4 subtype	P43114	Ptger4	Rattus norvegicus (Rat)	488
554270	Prostaglandin E2 receptor EP4 subtype	P35408	PTGER4	Homo sapiens (Human)	488
554261	Prostaglandin F2-alpha receptor	P43088	PTGFR	Homo sapiens (Human)	359
554269	Prostaglandin F2-alpha receptor	P43117	Ptgfr	Mus musculus (Mouse)	366
193596	Thromboxane A2 receptor	P21731	TBXA2R	Homo sapiens (Human)	343
554259	Thromboxane A2 receptor	P30987	Tbxa2r	Mus musculus (Mouse)	341

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