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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	27-hydroxycholesterol
Molecular formula	C27H46O2
IUPAC name	(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Molecular weight	402.663
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	7.1
Synonyms	CHEBI:76591 Cholest-5-ene-3beta,27-diol MolPort-042-624-515 (3?,25R)-Cholest-5-ene-3,26-diol 26-hydroxycholesterol(25R) 380C114 Cholest-5-ene-3,26,diol, (3beta,25R)- FYHRJWMENCALJY-YSQMORBQSA-N ZINC4097086 (25R)-26-Hydroxycholesterol (3beta,25R)-cholest-5-ene-3,26-diol 27-hydroxy-cholesterol(25R) 5-cholestene-3beta,27-diol AKOS027381276 Cholest-5-ene-3-beta,27-diol J-013261 (25R)-Cholest-5-ene-3beta,26-diol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol CHEMBL353882 CS-6949 SCHEMBL288494 (3b,25R)-Cholest-5-ene-3,26-diol 27 HC 5,25R-Cholesten-3beta,26-diol 6T2NA6P5SQ Cholest-5-ene-3-b,27-diol GTPL2752 (25R)-26-Hydroxycholesterol (3S,8S,9S,10R,13R,14S,17R)-17-((2R,6R)-7-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol BDBM20183 Cholest-5-ene-3beta,26-diol, (25R)- LMST01010088 (3-beta)-cholest-5-ene-3,26-diol 20380-11-4 27HC cholest-(25R)-5-en-3beta,26-diol D0H2YM UNII-6T2NA6P5SQ (1S,2R,5S,10S,11S,14R,15R)-14-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadec-7-en-5-ol (3beta,25R)-Cholest-5-ene-3,26,diol 27 OHC 5-cholestene-3 beta,27-diol AC1L3XNP Cholest-5-ene-3-beta,26-diol HY-N2371 (25R)-Cholest-5-ene-3b,26-diol (3S,8S,9S,10R,13R,14S,17R)-17-[(1R,5R)-6-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 27-OHC [ Show all ]
Inchi Key	FYHRJWMENCALJY-YSQMORBQSA-N
Inchi ID	InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
PubChem CID	123976
ChEMBL	N/A
IUPHAR	2752
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
553705	G-protein coupled receptor 183	P32249	GPR183	Homo sapiens (Human)	361

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