You can:
| Name | Muscarinic acetylcholine receptor M3 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Chrm3 |
| Synonym | M3R M3 receptor HM4 Chrm-3 cholinergic receptor, muscarinic 3, cardiac [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 589 |
| Amino acid sequence | MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL |
| UniProt | P08483 |
| Protein Data Bank | 4daj, 4u14, 4u15, 4u16, 5zhp |
| GPCR-HGmod model | N/A |
| 3D structure model | This structure is from PDB ID 4daj. |
| BioLiP | BL0433837, BL0433838,BL0433839, BL0300355,BL0300356, BL0300353,BL0300354, BL0223908,BL0223909,BL0223910,, BL0300352 |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL320 |
| IUPHAR | 15 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 681 |  CHEMBL1202052 | C22H39N3O3 | 393.572 | 4 / 1 | 3.1 | Yes |
| 2419 |  CHEMBL337023 | C24H33NO4 | 399.531 | 5 / 1 | 4.6 | Yes |
| 2981 |  CHEMBL553066 | C17H23ClN2O3 | 338.832 | 4 / 3 | N/A | N/A |
| 3093 |  PROPYLBENZILYLCHOLINE MUSTARD | C21H26ClNO3 | 375.893 | 4 / 1 | 4.2 | Yes |
| 3685 |  CHEMBL1202000 | C64H77N13O6 | 1124.41 | 13 / 4 | 7.7 | No |
| 4960 |  CHEMBL103189 | C23H26N4OS | 406.548 | 4 / 1 | 2.4 | Yes |
| 6385 |  CHEMBL302604 | C24H31N7O3 | 465.558 | 7 / 3 | -1.2 | Yes |
| 6411 |  CHEMBL68827 | C21H27N7O4S | 473.552 | 9 / 3 | -1.9 | Yes |
| 6619 |  carbachol | C6H15ClN2O2 | 182.648 | 3 / 1 | N/A | N/A |
| 7633 |  CHEMBL3298591 | C17H19N3O2S | 329.418 | 5 / 1 | 3.1 | Yes |
| 16195 |  CHEMBL294919 | C25H33N5O2 | 435.572 | 5 / 1 | 2.3 | Yes |
| 17058 |  CHEMBL321842 | C11H18N2O | 194.278 | 3 / 0 | 1.2 | Yes |
| 19930 |  CHEMBL297224 | C25H33N5O2 | 435.572 | 5 / 1 | 2.3 | Yes |
| 20545 |  AQ-RA 741 | C27H37N5O2 | 463.626 | 5 / 1 | 3.1 | Yes |
| 20820 |  CHEMBL320121 | C11H18N2O | 194.278 | 3 / 0 | 1.3 | Yes |
| 21405 |  CHEMBL68240 | C12H15NO2 | 205.257 | 3 / 1 | 1.2 | Yes |
| 22138 |  CHEMBL265521 | C13H20N2O | 220.316 | 3 / 0 | 1.9 | Yes |
| 22227 |  CHEMBL296405 | C25H33N5O2 | 435.572 | 5 / 1 | 2.3 | Yes |
| 22296 |  5-(1-Methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,4-oxadiazole | C8H11N3O | 165.196 | 4 / 0 | 0.4 | Yes |
| 22820 |  CHEMBL68771 | C20H24N6O2 | 380.452 | 6 / 2 | -0.8 | Yes |
| 22874 |  tropicamide | C17H20N2O2 | 284.359 | 3 / 1 | 1.5 | Yes |
| 25726 |  114724-56-0 | C9H13N3O | 179.223 | 4 / 0 | 0.8 | Yes |
| 27434 |  CHEMBL305403 | C28H31N7O3 | 513.602 | 7 / 3 | -0.1 | No |
| 29631 |  CHEMBL69458 | C35H43N7O5 | 641.773 | 8 / 3 | 2.3 | No |
| 30959 |  CHEMBL303678 | C20H21N5O3 | 379.42 | 5 / 1 | -0.4 | Yes |
| 32429 |  CHEMBL3298589 | C18H21ClN2O2S | 364.888 | 4 / 2 | N/A | N/A |
| 32432 |  CHEMBL3298590 | C18H21ClN2O2S | 364.888 | 4 / 2 | N/A | N/A |
| 33724 |  CHEMBL304112 | C30H30N6O4 | 538.608 | 7 / 1 | 1.5 | No |
| 35193 |  CHEMBL304599 | C19H22N6O4S | 430.483 | 8 / 2 | -1.3 | Yes |
| 36744 |  CHEMBL103529 | C23H26N4O2 | 390.487 | 4 / 1 | 2.6 | Yes |
| 36808 |  CHEMBL190815 | C21H25NO | 307.437 | 2 / 1 | 4.5 | Yes |
| 37361 |  Oxotremorine M | C11H19N2O+ | 195.286 | 1 / 0 | -0.1 | Yes |
| 37692 |  CHEMBL1916225 | C21H30FN3O3 | 391.487 | 5 / 1 | 3.1 | Yes |
| 37955 |  CHEMBL68709 | C25H23N5O3 | 441.491 | 5 / 1 | 1.2 | Yes |
| 39779 |  CHEMBL322293 | C11H18N2O | 194.278 | 3 / 0 | 1.4 | Yes |
| 40150 |  CHEMBL109120 | C10H16N2O | 180.251 | 3 / 0 | 0.8 | Yes |
| 40397 |  CHEMBL67700 | C15H19NO2 | 245.322 | 3 / 0 | 2.3 | Yes |
| 40934 |  CHEMBL295214 | C24H31N5O2 | 421.545 | 5 / 1 | 1.8 | Yes |
| 42083 |  DABDMA | C22H25NO | 319.448 | 2 / 0 | 4.2 | Yes |
| 45147 |  CHEMBL445106 | C12H14BrNO2 | 284.153 | 3 / 1 | 1.9 | Yes |
| 45937 |  CHEMBL1916228 | C21H31N3O4 | 389.496 | 5 / 1 | 2.6 | Yes |
| 46229 |  CHEMBL215180 | C37H41F3N4O4 | 662.754 | 8 / 3 | 4.3 | No |
| 48529 |  CHEMBL335302 | C24H33NO3 | 383.532 | 4 / 0 | 5.7 | No |
| 48871 |  CHEMBL38634 | C20H23NO | 293.41 | 2 / 0 | 4.2 | Yes |
| 49672 |  CHEMBL194870 | C23H22F2N2O2 | 396.438 | 5 / 2 | 2.8 | Yes |
| 50430 |  CHEMBL1202002 | C78H86N16O8 | 1375.65 | 16 / 4 | 9.0 | No |
| 51066 |  dicyclomine | C19H35NO2 | 309.494 | 3 / 0 | 5.5 | No |
| 51898 |  CHEMBL112244 | C36H59N7O2 | 621.915 | 7 / 3 | 4.3 | No |
| 52286 |  TBPB | C25H32N4O | 404.558 | 3 / 1 | 4.4 | Yes |
| 52462 |  CHEMBL300660 | C25H33N5O2 | 435.572 | 5 / 1 | 2.5 | Yes |
| 52937 |  CHEMBL296365 | C22H27N5O2 | 393.491 | 5 / 2 | 1.1 | Yes |
| 53264 |  (-)-Scopolamine methyl bromide | C18H24BrNO4 | 398.297 | 5 / 1 | N/A | N/A |
| 53449 |  CHEMBL45983 | C25H31N5O2 | 433.556 | 5 / 1 | 2.1 | Yes |
| 57154 |  UNII-JO67EL43YO | C14H18ClN2O2+ | 281.76 | 2 / 1 | 2.7 | Yes |
| 57218 |  CHEMBL134404 | C25H33NO4 | 411.542 | 5 / 1 | 4.8 | Yes |
| 57555 |  CHEMBL1202001 | C58H76N10O20 | 1233.3 | 26 / 12 | N/A | No |
| 58487 |  CHEMBL1202003 | C67H80N10O6 | 1121.44 | 10 / 4 | 9.9 | No |
| 59115 |  CHEMBL423722 | C22H23NO3 | 349.43 | 4 / 0 | 3.9 | Yes |
| 59354 |  CHEMBL1202002 | C86H94N16O24 | 1735.79 | 32 / 12 | N/A | No |
| 59984 |  CHEMBL558226 | C16H21Cl2N3O2 | 358.263 | 4 / 3 | N/A | N/A |
| 60654 |  Aprofene | C21H27NO2 | 325.452 | 3 / 0 | 3.8 | Yes |
| 60780 |  CHEMBL109068 | C13H20N2O | 220.316 | 3 / 0 | 2.0 | Yes |
| 62892 |  CHEMBL222424 | C27H27F2N3O | 447.53 | 4 / 1 | 4.6 | Yes |
| 62969 |  CHEMBL2323446 | C17H21NO4 | 303.358 | 5 / 0 | 2.6 | Yes |
| 62971 |  CHEMBL2323447 | C17H21NO4 | 303.358 | 5 / 0 | 2.6 | Yes |
| 64127 |  CHEMBL3298598 | C18H21ClIN3O2S | 505.799 | 5 / 1 | N/A | No |
| 66016 |  CHEMBL123573 | C7H14NO+ | 128.195 | 1 / 1 | -0.1 | Yes |
| 67135 |  CHEMBL3298334 | C18H21ClN2O2S | 364.888 | 4 / 2 | N/A | N/A |
| 68063 |  CHEMBL48980 | C23H29N5O2 | 407.518 | 5 / 1 | 1.6 | Yes |
| 74410 |  CHEMBL1169543 | C23H26N2O2 | 362.473 | 3 / 0 | 4.0 | Yes |
| 74415 |  AC1O1JMR | C23H26N2O2 | 362.473 | 3 / 0 | 4.0 | Yes |
| 74417 |  CHEMBL439867 | C23H26N2O2 | 362.473 | 3 / 0 | 4.0 | Yes |
| 74424 |  Solifenacin | C23H26N2O2 | 362.473 | 3 / 0 | 4.0 | Yes |
| 74427 |  CHEMBL606902 | C23H26N2O2 | 362.473 | 3 / 0 | 4.0 | Yes |
| 74445 |  CHEMBL306182 | C21H24INO3 | 465.331 | 4 / 0 | N/A | N/A |
| 75350 |  CHEMBL372983 | C23H32N2O2 | 368.521 | 3 / 0 | 4.7 | Yes |
| 75534 |  CHEMBL322555 | C13H20N2O | 220.316 | 3 / 0 | 1.9 | Yes |
| 76352 |  ondansetron | C18H19N3O | 293.37 | 2 / 0 | 2.3 | Yes |
| 77042 |  CHEMBL192065 | C23H23NO3 | 361.441 | 4 / 1 | 3.2 | Yes |
| 444855 |  CHEMBL3329755 | C23H25F3N4O3S | 494.533 | 8 / 1 | 3.4 | Yes |
| 82130 |  Himbacine | C22H35NO2 | 345.527 | 3 / 0 | 5.0 | Yes |
| 84312 |  SPIPETHIANE | C20H23NS | 309.471 | 2 / 0 | 4.7 | Yes |
| 85948 |  CHEMBL111529 | C10H17NO2 | 183.251 | 3 / 0 | 1.2 | Yes |
| 85949 |  CHEMBL325322 | C10H17NO2 | 183.251 | 3 / 0 | 1.2 | Yes |
| 85951 |  CHEMBL325322 | C10H17NO2 | 183.251 | 3 / 0 | 1.2 | Yes |
| 86061 |  CHEMBL2323443 | C17H20N2O6 | 348.355 | 7 / 0 | 2.4 | Yes |
| 86062 |  CHEMBL2323442 | C17H20N2O6 | 348.355 | 7 / 0 | 2.4 | Yes |
| 548901 |  CHEMBL3923597 | C19H25N5O3S | 403.501 | 8 / 2 | 1.9 | Yes |
| 87079 |  CHEMBL422407 | C25H31N7O4 | 493.568 | 7 / 3 | -1.3 | Yes |
| 548927 |  CHEMBL3921095 | C15H21N5O3S | 351.425 | 8 / 1 | 2.1 | Yes |
| 88194 |  CHEMBL194628 | C21H24N2O2 | 336.435 | 3 / 1 | 3.8 | Yes |
| 88518 |  CHEMBL190459 | C23H29NO4 | 383.488 | 5 / 1 | 3.3 | Yes |
| 97249 |  Cogentinol | C21H25NO | 307.437 | 2 / 0 | 4.5 | Yes |
| 99149 |  CHEMBL1202052 | C24H41N3O7 | 483.606 | 8 / 3 | N/A | N/A |
| 100115 |  CHEMBL2321893 | C17H20ClNO4 | 337.8 | 5 / 0 | 3.2 | Yes |
| 100118 |  CHEMBL2323441 | C17H20ClNO4 | 337.8 | 5 / 0 | 3.2 | Yes |
| 101221 |  CHEMBL1201994 | C74H92N10O22 | 1473.6 | 28 / 10 | N/A | No |
| 103381 |  CHEMBL2112432 | C24H27N5O | 401.514 | 4 / 0 | 3.1 | Yes |
| 103409 |  CHEMBL337227 | C25H33NO3 | 395.543 | 4 / 0 | 5.8 | No |
| 103511 |  CHEMBL2315680 | C20H27F3N4O3 | 428.456 | 8 / 1 | 2.5 | Yes |
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