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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Rattus norvegicus (Rat)
Gene	Chrm3
Synonym	M3R M3 receptor HM4 Chrm-3 cholinergic receptor, muscarinic 3, cardiac cholinergic receptor, muscarinic 3 cholinergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	P08483
Protein Data Bank	4daj, 4u14, 4u15, 4u16, 5zhp
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4daj.
BioLiP	BL0433837, BL0433838,BL0433839, BL0300355,BL0300356, BL0300353,BL0300354, BL0223908,BL0223909,BL0223910,, BL0300352
Therapeutic Target Database	N/A
ChEMBL	CHEMBL320
IUPHAR	15
DrugBank	N/A

Ligand

Name	Oxotremorine M
Molecular formula	C11H19N2O+
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium
Molecular weight	195.286
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	-0.1
Synonyms	CHEBI:38322 GTPL8595 Lopac-O-100 NCGC00015758-04 PDSP2_000569 AC1L1ILG CHEMBL44674 KBio2_002539 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium NINDS_000379 Tocris-1067 2-Butyn-1-aminium, N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)- C11H19N2O DivK1c_000379 KBioSS_002548 NCGC00015758-02 oxotremorine-M ZINC1547932 63939-65-1 CHEMBL23957 IDI1_000379 Lopac0_000954 NCGC00024979-01 SCHEMBL4542695 AC1Q6FK0 D02WTM KBio2_005107 N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium OXO-M Trimethyl-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-ammonium; iodide CCG-205035 GTPL303 L000458 NCGC00015758-03 PDSP1_000571 [3H]oxotremorine-M KBio1_000379 LS-176344 NCGC00024979-02 Spectrum_001982 BDBM50005677 D0G4CG KBio2_007675 NCGC00015758-01 trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium [ Show all ]
Inchi Key	CANZROMYQDHYHR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
PubChem CID	4629
ChEMBL	CHEMBL44674
IUPHAR	303, 8595
BindingDB	50005677
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	8700.0 nM	PMID8968358	BindingDB

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