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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Aprofene
Molecular formula	C21H27NO2
IUPAC name	2-(diethylamino)ethyl 2,2-diphenylpropanoate
Molecular weight	325.452
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.8
Synonyms	4-09-00-02535 (Beilstein Handbook Reference) Aprofen Aprophenum CHEMBL26505 LS-124652 SR-01000883700 2,2-diphenylpropanoic acid N,N-diethylaminoethyl ester AKOS003658410 Aprofeno Benzeneacetic acid, alpha-methyl-alpha-phenyl-, 2-(diethylamino)ethyl ester (9CI) DSSTox_CID_26294 NCGC00160676-01 Tox21_111979 .alpha.,.alpha.-Diphenylpropionic acid .beta.-diethylaminoethyl ester 2-(Diethylamino)ethyl 2,2-diphenylpropanoate # alpha-Methyl-alpha-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester Aprofenum [INN-Latin] CAS-3563-01-7 DTXSID8046294 Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester ZINC2003680 2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester 2589-00-6 (hydrochloride) BDBM50005685 D0P1FJ MCULE-3053971242 SR-01000883700-1 2,2-Diphenylpropionic acid 2-diethylaminoethyl ester alpha,alpha-Diphenylpropionic acid 2-diethylaminoethyl ester Aprofeno [INN-Spanish] BRD-K48282247-001-01-4 DSSTox_GSID_46294 NCGC00160676-02 Tox21_111979_1 .alpha.,.alpha.-Diphenylpropionic acid 2-diethylaminoethyl ester 2-diethylaminoethyl 2,2-diphenylpropanoate API0015885 Aprophen L000719 SCHEMBL2354824 2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester(Aprophen) 3563-01-7 AC1L2FLD Aprofene [INN] Benzeneacetic acid, alpha-methyl-alpha-phenyl-, 2-(diethylamino)ethyl ester DIDYGLSKVUKRRP-UHFFFAOYSA-N MolPort-001-783-504 STK182867 2-(Diethylamino)ethyl 2,2-diphenylpropanoate alpha,alpha-Diphenylpropionic acid beta-diethylaminoethyl ester Aprofenum BRN 2509326 DSSTox_RID_81519 PL791XXJ7B UNII-PL791XXJ7B .alpha.-Methyl-.alpha.-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester 2-Diethylaminoethyl 2,2-diphenylpropionate [ Show all ]
Inchi Key	DIDYGLSKVUKRRP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
PubChem CID	71128
ChEMBL	CHEMBL26505
IUPHAR	N/A
BindingDB	50005685
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
60655	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
60659	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
60653	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
60657	Muscarinic acetylcholine receptor M2	P10980	Chrm2	Rattus norvegicus (Rat)	466
60654	Muscarinic acetylcholine receptor M3	P08483	Chrm3	Rattus norvegicus (Rat)	589
60660	Muscarinic acetylcholine receptor M3	P20309	CHRM3	Homo sapiens (Human)	590
60656	Muscarinic acetylcholine receptor M4	P08173	CHRM4	Homo sapiens (Human)	479
60658	Muscarinic acetylcholine receptor M4	P17200	CHRM4	Gallus gallus (Chicken)	490

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